4-(3-bromo-4-methoxyphenyl)-4-oxobutanoic acid

Base Information

• Chemical Name: 4-(3-bromo-4-methoxyphenyl)-4-oxobutanoic acid
• CAS No.: 46719-55-5
• Molecular Formula: C11H11BrO4
• Molecular Weight: 287.11
• Hs Code.: 2918990090
• Mol file: 46719-55-5.mol

Synonyms:4-(3-bromo-4-methoxyphenyl)-4-oxobutanoic acid

Chemical Property of 4-(3-bromo-4-methoxyphenyl)-4-oxobutanoic acid

Chemical Property:

• PSA: 63.60000
• LogP: 2.50520

Purity/Quality:

≥99% ^*data from raw suppliers

4-(3-Bromo-4-methoxyphenyl)-4-oxobutanoicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(3-bromo-4-methoxyphenyl)-4-oxobutanoic acid

There total 1 articles about 4-(3-bromo-4-methoxyphenyl)-4-oxobutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

succinic acid anhydride (108-30-5) + 2-bromoanisole (578-57-4) → 4-(3-bromo-4-methoxyphenyl)-4-oxobutanoic acid (46719-55-5)

Guidance literature:

With aluminum (III) chloride; In dichloromethane; at 20 ℃; for 16h; Inert atmosphere; Cooling with ice;

DOI:10.1002/cmdc.201900538

Reference yield: 89.0%

4-(3-bromo-4-methoxyphenyl)-4-oxobutanoic acid (46719-55-5) → 6-(3-bromo-4-methoxyphenyl)-4,5-dihydropyridazin-3(2H)-one

Guidance literature:

With hydrazine hydrate; In ethanol; at 85 ℃; for 1h; Inert atmosphere;

DOI:10.1002/cmdc.202000136

upstream raw materials:

succinic acid anhydride

2-bromoanisole

Refernces

• 1、 Sijm, Maarten,Sterk, Geert Jan,Caljon, Guy,Maes, Louis,de Esch, Iwan J. P.,Leurs, Rob. "Structure-Activity Relationship of Phenylpyrazolones against Trypanosoma cruzi". supporting information. p. 1310 - 1321. Retrieved 2020/05/08.