5-bromo-6-chloronicotinoyl chloride

Base Information

• Chemical Name: 5-bromo-6-chloronicotinoyl chloride
• CAS No.: 78686-84-7
• Molecular Formula: C6H2BrCl2NO
• Molecular Weight: 254.898
• Hs Code.: 2933998090
• Mol file: 78686-84-7.mol

Synonyms:5-bromo-6-chloronicotinoyl chloride;3-PYRIDINECARBONYL CHLORIDE, 5-BROMO-6-CHLORO

Chemical Property of 5-bromo-6-chloronicotinoyl chloride

Chemical Property:

• PSA: 29.96000
• LogP: 2.87650

Purity/Quality:

99% ^*data from raw suppliers

5-Bromo-6-chloronicotinoyl chloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-bromo-6-chloronicotinoyl chloride

There total 3 articles about 5-bromo-6-chloronicotinoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-bromo-6-chloronicotinic acid (29241-62-1) → 3-bromo-2-chloro-5-pyridinecarbonyl chloride (78686-84-7)

Guidance literature:

With thionyl chloride; for 1h; Heating;

DOI:10.1021/je00025a033

Reference yield:

5-bromo-6-hydroxy-3-pyridinecarboxylic acid (41668-13-7) → 3-bromo-2-chloro-5-pyridinecarbonyl chloride (78686-84-7)

Guidance literature:

With phosphorus pentachloride; trichlorophosphate; Heating / reflux;

Reference yield:

5,6-Dibromnicotinsaeure (29241-64-3) → 5,6-dibromo-3-pyridinecarboxylic acid chloride (1620099-10-6) + 3-bromo-2-chloro-5-pyridinecarbonyl chloride (78686-84-7)

Guidance literature:

With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; at 0 - 20 ℃; for 5h; Inert atmosphere;

DOI:10.1021/jm5001979

upstream raw materials:

5-bromo-6-chloronicotinic acid

5-bromo-6-hydroxy-3-pyridinecarboxylic acid

5,6-Dibromnicotinsaeure

Refernces

• 1、 Bondeson, Daniel P.,Burslem, George M.,Crews, Craig M.. "Scaffold hopping enables direct access to more potent PROTACs with: In vivo activity". supporting information. p. 6890 - 6892. Retrieved 2020/07/04.
• 2、 -. "OXADIAZOLE MODULATORS OF S1P METHODS OF MAKING AND USING". Paragraph 0198. . Retrieved 2017/01/23.