6-fluoro-3,20-dioxopregna-4,6-dien-17-yl acetate

Base Information

• Chemical Name: 6-fluoro-3,20-dioxopregna-4,6-dien-17-yl acetate
• CAS No.: 2162-49-4
• Molecular Formula: C23H29FO4
• Molecular Weight: 388.4724
• Mol file: 2162-49-4.mol

Synonyms:

Chemical Property of 6-fluoro-3,20-dioxopregna-4,6-dien-17-yl acetate

Chemical Property:

• Vapor Pressure: 1E-09mmHg at 25°C
• Boiling Point: 489.4°C at 760 mmHg
• Flash Point: 240.7°C
• Density: 1.2g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-fluoro-3,20-dioxopregna-4,6-dien-17-yl acetate

There total 12 articles about 6-fluoro-3,20-dioxopregna-4,6-dien-17-yl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

17α-acetoxy-6α-fluoropregn-4-ene-3,20-dione (336-78-7) → 6-Fluor-6-dehydro-17α-acetoxy-progesteron (2162-49-4)

Guidance literature:

With 1-pentyl acetate; chloranil; acetic acid;

DOI:10.1021/ja01531a035

Reference yield:

17-acetoxy-6β-fluoro-3β,5-dihydroxy-5α-pregnan-20-one (1813-06-5) → 6-Fluor-6-dehydro-17α-acetoxy-progesteron (2162-49-4)

Guidance literature:

Multi-step reaction with 3 steps

1: CrO₃; acetone

2: HCl

3: tetrachloro-<1,4>benzoquinone; pentyl acetate; acetic acid

With chromium(VI) oxide; hydrogenchloride; 1-pentyl acetate; chloranil; acetic acid; acetone;

DOI:10.1021/ja01531a035

Reference yield:

17-acetoxy-3β-formyloxy-pregn-5-en-20-one (83984-86-5) → 6-Fluor-6-dehydro-17α-acetoxy-progesteron (2162-49-4)

Guidance literature:

Multi-step reaction with 6 steps

1: methanol. KOH

2: chloroform; monoperoxyphthalic acid; diethyl ether

3: ether BF₃

4: CrO₃; acetone

5: HCl

6: tetrachloro-<1,4>benzoquinone; pentyl acetate; acetic acid

With chromium(VI) oxide; hydrogenchloride; potassium hydroxide; monoperoxyphthalic acid; diethyl ether; chloroform; 1-pentyl acetate; boron trifluoride diethyl etherate; chloranil; acetic acid; acetone;

DOI:10.1021/ja01531a035

upstream raw materials:

17α-acetoxy-6α-fluoropregn-4-ene-3,20-dione

17α-acetoxy-6α,7α-epoxy-4-pregnen-3,20-dione

17-acetoxy-6β-fluoro-3β,5-dihydroxy-5α-pregnan-20-one

17-acetoxy-3β-formyloxy-pregn-5-en-20-one