SuMatriptan N-Oxide

Base Information

• Chemical Name: SuMatriptan N-Oxide
• CAS No.: 212069-94-8
• Molecular Formula: C₁₄H₂₁N₃O₃S
• Molecular Weight: 311.405
• Mol file: 212069-94-8.mol

Synonyms:SuMatriptan N-Oxide;3-[2-(DiMethyloxidoaMino)ethyl]-N-Methyl-1H-indole-5-MethanesulfonaMide;GR 112504;SuMatriptan Succinate IMpurity – D (EP/BP);SuMatriptan EP IMpurity D

Chemical Property of SuMatriptan N-Oxide

Chemical Property:

• Melting Point: 190-193 °C(Solv: acetone (67-64-1))
• PKA: 11.28±0.40(Predicted)
• PSA: 99.77000
• LogP: 2.82640
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: DMSO (Very Slightly, Heated), Methanol (Very Slightly, Heated), Water (Slightly)

Purity/Quality:

99.90% ^*data from raw suppliers

Sumatriptan N-oxide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A degradation product of the antimigraine drug Sumatriptan (S810000). Sumatriptan N-Oxide (Sumatriptan EP Impurity D) is the degradation product of the antimigraine drug Sumatriptan (S810000).

Technology Process of SuMatriptan N-Oxide

There total 2 articles about SuMatriptan N-Oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

sumatripan (103628-46-2) → sumatriptan N-oxide (212069-94-8)

Guidance literature:

With sodium tungstate (VI) dihydrate; methanesulfonic acid; dihydrogen peroxide; In methanol; water; at 50 - 55 ℃;

Reference yield:

sumatripan (103628-46-2) → sumatriptan N-oxide (212069-94-8) + C14H21N3O3S + C14H21N3O4S + C14H21N3O4S + C14H21N3O5S

Guidance literature:

With dihydrogen peroxide; at 20 ℃; for 240h;

DOI:10.1002/jms.4266

upstream raw materials:

sumatripan

Refernces

• 1、 Ray, Puma Chandra,Mittapelli, Vasantha,Chauhan, Yogendra Kumar,Konudula, Babu Rao,Tyagi, Om Dutt. "Tungstale-catalyzed oxidation of triptans with hydrogen peroxide: A novel method for the synthesis of N,N- Dimethyltryptamine N-oxides". experimental part. p. 134 - 136. Retrieved 2009/12/01.