methyl2-methyl-2-(4-nitrophenyl)propanoate

Base Information

• Chemical Name: methyl2-methyl-2-(4-nitrophenyl)propanoate
• CAS No.: 59115-08-1
• Molecular Formula: C11H13NO4
• Molecular Weight: 223.229
• Mol file: 59115-08-1.mol

Synonyms:methyl2-methyl-2-(4-nitrophenyl)propanoate

Chemical Property of methyl2-methyl-2-(4-nitrophenyl)propanoate

Chemical Property:

• PSA: 72.12000
• LogP: 2.56860

Purity/Quality:

99% ^*data from raw suppliers

Methyl2-Methyl-2-(4-nitrophenyl)propanoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl2-methyl-2-(4-nitrophenyl)propanoate

There total 16 articles about methyl2-methyl-2-(4-nitrophenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl (4-nitrophenyl)acetate (2945-08-6) + methyl iodide (74-88-4) → methyl 2-methyl-2-(4-nitrophenyl)propanoate (59115-08-1)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2017.08.005

Reference yield: 99.0%

4-nitrobenzeneacetic acid (104-03-0) + methyl iodide (74-88-4) → methyl 2-methyl-2-(4-nitrophenyl)propanoate (59115-08-1)

Guidance literature:

With 18-crown-6 ether; sodium hydride; In DMF (N,N-dimethyl-formamide); at 0 - 25 ℃;

Reference yield: 98.0%

1-methoxy-2-methyl-1-trimethylsiloxy-1-propene (31469-15-5) + para-nitrophenyl bromide (586-78-7) → methyl 2-methyl-2-(4-nitrophenyl)propanoate (59115-08-1)

Guidance literature:

With zinc(II) fluoride; tri-tert-butyl phosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 80 ℃; for 12h;

DOI:10.1021/ja036792p

upstream raw materials:

1-methoxy-2-methyl-1-trimethylsiloxy-1-propene

nitrobenzene

Methyl isobutyrate

para-nitrophenyl bromide

Downstream raw materials:

1-methyl-1-(4-nitro-phenyl)-ethylamine

1-(2-(cyclohex-1-en-1-yl)propan-2-yl)-4-nitrobenzene

2-(4-{4-[5-(5-chloro-1H-benzimidazol-2-yl)pyridin-2-yl]piperazin-1-yl}phenyl)-2-methylpropanoic acid

methyl 2-(4-{4-[5-(5-chloro-1H-benzimidazol-2-yl)pyridin-2-yl]piperazin-1-yl}phenyl)-2-methylpropanoate

Refernces

• 1、 -. "(PYRIDIN-2-YL)AMINE DERIVATIVES AS TGF-BETA R1 (ALK5) INHIBITORS FOR THE TREATMENT OF CANCER". Paragraph 00363. . Retrieved 2020/07/15.
• 2、 Deplano, Alessandro,Morgillo, Carmine Marco,Demurtas, Monica,Bj?rklund, Emmelie,Cipriano, Mariateresa,Svensson, Mona,Hashemian, Sanaz,Smaldone, Giovanni,Pedone, Emilia,Luque, F. Javier,Cabiddu, Maria G.,Novellino, Ettore,Fowler, Christopher J.,Catalanotti, Bruno,Onnis, Valentina. "Novel propanamides as fatty acid amide hydrolase inhibitors". . p. 523 - 542. Retrieved 2017/05/29.