METHYL 3,6-DICHLOROPYRAZINE-2-CARBOXYLATE

Base Information

• Chemical Name: METHYL 3,6-DICHLOROPYRAZINE-2-CARBOXYLATE
• CAS No.: 356783-14-7
• Molecular Formula: C₆H₄Cl₂N₂O₂
• Molecular Weight: 207.016
• Mol file: 356783-14-7.mol

Synonyms:METHYL 3,6-DICHLOROPYRAZINE-2-CARBOXYLATE

Chemical Property of METHYL 3,6-DICHLOROPYRAZINE-2-CARBOXYLATE

Chemical Property:

• PSA: 52.08000
• LogP: 1.57000
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

Methyl3,6-dichloropyrazine-2-carboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 3,6-DICHLOROPYRAZINE-2-CARBOXYLATE

There total 3 articles about METHYL 3,6-DICHLOROPYRAZINE-2-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-amino-6-chloropyrazine-2-carboxylic acid methyl ester (1458-03-3) → methyl 3,6-dichloro-2-pyrazinecarboxylate (356783-14-7)

Guidance literature:

3-amino-6-chloropyrazine-2-carboxylic acid methyl ester; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 1h;

With copper(l) chloride; In water; for 6h;

Reference yield:

cuprous (I) chloride + 3-amino-6-chloropyrazine-2-carboxylic acid methyl ester (1458-03-3) → methyl 3,6-dichloro-2-pyrazinecarboxylate (356783-14-7)

Guidance literature:

With sodium chloride; sodium nitrite; In tetrahydrofuran; hydrogenchloride; water; ethyl acetate;

Reference yield:

Methyl 3-amino-2-pyrazinecarboxylate (16298-03-6) → methyl 3,6-dichloro-2-pyrazinecarboxylate (356783-14-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 24 h / 80 °C

2.1: hydrogenchloride; sodium nitrite / water / 1 h / 0 °C

2.2: 6 h

With hydrogenchloride; N-chloro-succinimide; sodium nitrite; In water; N,N-dimethyl-formamide;

upstream raw materials:

3-amino-6-chloropyrazine-2-carboxylic acid methyl ester

Methyl 3-amino-2-pyrazinecarboxylate

Downstream raw materials:

methyl 3,6-difluoropyrazine-2-carboxylate

3,6-dichloro-2-pyrazinecarboxylic acid

Refernces

• 1、 -. "Novel pyrazine derivatives or salts thereof, pharmaceutical composition containing the same, and production intermediates thereof". . . Retrieved 2008/06/13.