3-Amino-2-phenylamino-pyridine

Base Information

• Chemical Name: 3-Amino-2-phenylamino-pyridine
• CAS No.: 41010-49-5
• Molecular Formula: C11H11N3
• Molecular Weight: 185.228
• Hs Code.: 2933399090
• European Community (EC) Number: 819-086-3
• DSSTox Substance ID: DTXSID30443365
• Nikkaji Number: J2.618.999C
• Wikidata: Q82261126
• Mol file: 41010-49-5.mol

Synonyms:41010-49-5;3-Amino-2-phenylamino-pyridine;2-N-phenylpyridine-2,3-diamine;N2-phenylpyridine-2,3-diamine;N2-Phenyl-2,3-pyridinediamine;3-Amino-2-phenylaminopyridine;3-amino-2-anilinopyridine;N-phenylpyridine-2,3-diamine;SCHEMBL1859867;3-Amino-N-phenylpyridin-2-amine;DTXSID30443365;OLQLKEGDKARDNO-UHFFFAOYSA-N;HMS1627H03;MFCD00823189;AKOS000264902;CCG-133688;SB54307;BB 0255015;CS-0230955;FT-0681531;EN300-106357;Z367654964

Chemical Property of 3-Amino-2-phenylamino-pyridine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 356.003°C at 760 mmHg
• Flash Point: 169.105°C
• PSA: 50.94000
• Density: 1.227g/cm³
• LogP: 3.06160
• XLogP3: 2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 185.095297364
• Heavy Atom Count: 14
• Complexity: 166

Purity/Quality:

98%min ^*data from raw suppliers

N2-Phenyl-2,3-pyridinediamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)NC2=C(C=CC=N2)N

Technology Process of 3-Amino-2-phenylamino-pyridine

There total 10 articles about 3-Amino-2-phenylamino-pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3-nitro-2-phenylaminopyridine (34949-41-2) → 3-amino-2-phenylaminopyridine (41010-49-5)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In ethanol; for 1h; under 760.051 Torr;

Reference yield: 85.0%

2-chloro-3-aminopyridine (6298-19-7) + aniline (62-53-3) → 3-amino-2-phenylaminopyridine (41010-49-5)

Guidance literature:

With hydrogen bromide; In diethylene glycol; at 170 ℃; for 5h;

Reference yield:

2-Chloro-3-nitropyridine (5470-18-8,34515-82-7) → 3-amino-2-phenylaminopyridine (41010-49-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 57 percent / aq. HCl / 2-methoxy-ethanol / 18 h / Heating

2: H₂ / 5 percent Pd/C / methanol / 3 h

With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol; 2-methoxy-ethanol;

DOI:10.1021/jm9804681

upstream raw materials:

2-chloro-3-aminopyridine

aniline

3-nitro-2-phenylaminopyridine

2-Chloro-3-nitropyridine

Downstream raw materials:

C₁₃H₉N₃O₂*ClH

C₂₀H₁₄FN₅O

C₂₄H₁₇N₅O₂

C₂₁H₁₇N₅O₃

Refernces

• 1、 -. "Heterocyclic compound and organic light emitting device including the same". Paragraph 0521; 0534-0537; 0628; 0633-0636. . Retrieved 2020/07/15.
• 2、 -. "Pt (II) photoluminescence compound based on pyridinoimidazole derivative and preparation method thereof". Paragraph 0057; 0059; 0064; 0066; 0071; 0073. . Retrieved 2020/12/15.