3-dimethylaminomethyl-4-nitroindole

Base Information

• Chemical Name: 3-dimethylaminomethyl-4-nitroindole
• CAS No.: 7150-46-1
• Molecular Formula: C11H13 N3 O2
• Molecular Weight: 219.243
• Hs Code.: 2933990090
• Mol file: 7150-46-1.mol

Synonyms:Indole, 3-(dimethylaminomethyl)-4-nitro-(6CI); 4-Nitrogramine; N,N-Dimethyl-1-(4-nitro-1H-indol-3-yl)methanamine; NSC 71845

Chemical Property of 3-dimethylaminomethyl-4-nitroindole

Chemical Property:

• Vapor Pressure: 6.51E-06mmHg at 25°C
• Boiling Point: 377.9°Cat760mmHg
• Flash Point: 182.4°C
• PSA: 64.85000
• Density: 1.287g/cm³
• LogP: 2.66090

Purity/Quality:

99% ^*data from raw suppliers

4-Nitrogramine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-dimethylaminomethyl-4-nitroindole

There total 12 articles about 3-dimethylaminomethyl-4-nitroindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-nitro-1H-indoIe (4769-97-5) + N-(chloromethyl)dimethylamine (30438-74-5) → 4-nitrogramine (7150-46-1)

Guidance literature:

In acetic acid;

DOI:10.1016/S0040-4039(00)78433-4

Reference yield: 82.5%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 4-nitro-1H-indoIe (4769-97-5) + dimethyl amine (124-40-3) → 4-nitrogramine (7150-46-1)

Guidance literature:

In water; acetic acid; for 12h; Ambient temperature;

DOI:10.1248/cpb.33.3696

Reference yield: 75.0%

4-nitro-1H-indole-3-carbaldehyde (10553-11-4) → 4-nitrogramine (7150-46-1) + 4-nitroindole-3-yl methanol (124549-51-5)

Guidance literature:

With sodium tetrahydroborate; N,N-dimethylammonium chloride; In water; for 2.5h; Ambient temperature;

upstream raw materials:

4-nitro-1H-indoIe

eschenmoser's salt

formaldehyd

dimethyl amine

Downstream raw materials:

4-nitro-1H-indoIe

4-nitroindole-3-acetonitrile

(+/-)-indolactam-V

(+/-)-epi-indolactam V

Refernces

• 1、 -. "TRICYCLIC ANILIDE HETEROCYCLIC CGRP RECEPTOR ANTAGONISTS". Page/Page column 56-57. . Retrieved 2009/01/24.
• 2、 -. "SPIROHYDANTOIN TRICYCLIC CGRP RECEPTOR ANTAGONISTS". Page/Page column 116. . Retrieved 2008/06/13.