BOC-L-2-(5-CHLOROTHIENYL)ALANINE

Base Information

• Chemical Name: BOC-L-2-(5-CHLOROTHIENYL)ALANINE
• CAS No.: 190319-94-9
• Molecular Formula: C12H16ClNO4S
• Molecular Weight: 305.78
• Mol file: 190319-94-9.mol

Synonyms:BOC-L-2-(5-CHLOROTHIENYL)ALANINE;Boc-3-(5-chlorothien-2-yl)-L-alanine

Chemical Property of BOC-L-2-(5-CHLOROTHIENYL)ALANINE

Chemical Property:

• PSA: 103.87000
• LogP: 3.31280

Purity/Quality:

99%+, ^*data from raw suppliers

BOC-3-(5-CHLOROTHIEN-3-YL)-L-ALANINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BOC-L-2-(5-CHLOROTHIENYL)ALANINE

There total 3 articles about BOC-L-2-(5-CHLOROTHIENYL)ALANINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

di-tert-butyl dicarbonate (24424-99-5) + (S)-2-amino-3-(5-chlorothiophen-2-yl)propanoic acid (911471-88-0) → (S)-2-tert-Butoxycarbonylamino-3-(5-chloro-thiophen-2-yl)-propionic acid (190319-94-9)

Guidance literature:

With aq. alkali;

DOI:10.1007/BF00807581

Reference yield:

D,L-N-acetyl-β-2-thienylalanine (67206-07-9) → (S)-2-tert-Butoxycarbonylamino-3-(5-chloro-thiophen-2-yl)-propionic acid (190319-94-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 69 percent / NCS / CCl₄ / 2 h / Heating

2: 0.1 M potassium phosphate buffer / 24 h / 40 °C / acylase I (E_.C_. 3.5.1.14, from Aspergillus melleus), pH: 7.5-8

3: 54 percent / aq. alkali

With N-chloro-succinimide; potassium phosphate buffer; In tetrachloromethane;

DOI:10.1007/BF00807581

Reference yield:

2-Acetylamino-3-(5-chloro-thiophen-2-yl)-propionic acid (190319-92-7) → (S)-2-tert-Butoxycarbonylamino-3-(5-chloro-thiophen-2-yl)-propionic acid (190319-94-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 0.1 M potassium phosphate buffer / 24 h / 40 °C / acylase I (E_.C_. 3.5.1.14, from Aspergillus melleus), pH: 7.5-8

2: 54 percent / aq. alkali

With potassium phosphate buffer;

DOI:10.1007/BF00807581

upstream raw materials:

di-tert-butyl dicarbonate

(S)-2-amino-3-(5-chlorothiophen-2-yl)propanoic acid

2-Acetylamino-3-(5-chloro-thiophen-2-yl)-propionic acid

D,L-N-acetyl-β-2-thienylalanine

Refernces