Metoprolol (succinate)

Base Information

• Chemical Name: Metoprolol (succinate)
• CAS No.: 207983-04-8
• Molecular Weight: 385.45194
• Mol file: 207983-04-8.mol

Synonyms:

Chemical Property of Metoprolol (succinate)

Chemical Property:

Purity/Quality:

99,9% ^*data from raw suppliers

Metoprolol (succinate) ≥98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Metoprolol (succinate)

There total 7 articles about Metoprolol (succinate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.8%

succinic acid (110-15-6) + 4-(2-methoxyethyl)phenol (56718-71-9) + isopropylamine (75-31-0) + epichlorohydrin (106-89-8,24969-06-0,13403-37-7) → metoprolol succinate (207983-04-8,98418-47-4)

Guidance literature:

4-(2-methoxyethyl)phenol; epichlorohydrin; With sodium hydroxide; In water; at 30 - 40 ℃; for 5h;

isopropylamine; In water; at 20 - 30 ℃; for 5h;

succinic acid; In acetone; at 20 - 35 ℃; Temperature; Solvent;

Reference yield: 97.0%

(RS)-metoprolol (51384-51-1,37350-58-6) + succinic acid (110-15-6) → metoprolol succinate (207983-04-8,98418-47-4)

Guidance literature:

In water; acetone; at 50 - 65 ℃; for 0.5h;

Reference yield: 95.6%

succinic acid (110-15-6) + isopropylamine (75-31-0) + 2-[4-(2'-methoxyethyl)phenoxymethyl]oxirane (56718-70-8) → metoprolol Succinate (207983-04-8,98418-47-4)

Guidance literature:

isopropylamine; 2-[4-(2'-methoxyethyl)phenoxymethyl]oxirane; In ethanol; at 50 - 92 ℃; Flow reactor;

succinic acid; In ethanol; Reflux;

upstream raw materials:

(RS)-metoprolol

succinic acid

4-(2-methoxyethyl)phenol

2-[4-(2'-methoxyethyl)phenoxymethyl]oxirane

Refernces

• 1、 -. "Method for preparing metoprolol succinate". Paragraph 0036-0068. . Retrieved 2020/09/16.
• 2、 -. "Succinic acid δ S-metoprolol of the crystal and its preparation method and application". Paragraph 0034; 0035. . Retrieved 2016/10/17.