Technology Process of 7-Methoxy-4-(3-pyridinyl)-6-[2-(2-quinolinyl)ethoxy]quinazoline
There total 12 articles about 7-Methoxy-4-(3-pyridinyl)-6-[2-(2-quinolinyl)ethoxy]quinazoline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
di-tert-butyl-diazodicarboxylate; triphenylphosphine;
In
tetrahydrofuran;
at 20 ℃;
Inert atmosphere;
DOI:10.1021/jm2001508
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: iron; ammonium chloride / methanol; water / 24 h / 90 °C
2.1: lithium hydroxide / tetrahydrofuran; methanol; water / 6 h / 75 °C
2.2: pH 7
3.1: ethyl methyl ether / 24 h / 130 °C / Inert atmosphere
3.2: 20 °C
4.1: trichlorophosphate / 3 h / 120 °C / Inert atmosphere
5.1: tris(dibenzylideneacetone)dipalladium(0) chloroform complex; caesium carbonate; tricyclohexylphosphine / 1,4-dioxane / 24 h / 100 °C / Inert atmosphere
6.1: methoxybenzene / trifluoroacetic acid / 24 h / 75 °C / Inert atmosphere
7.1: di-tert-butyl-diazodicarboxylate; triphenylphosphine / tetrahydrofuran / 20 °C / Inert atmosphere
With
tris(dibenzylideneacetone)dipalladium(0) chloroform complex; di-tert-butyl-diazodicarboxylate; iron; ammonium chloride; caesium carbonate; methoxybenzene; triphenylphosphine; lithium hydroxide; trichlorophosphate; tricyclohexylphosphine;
In
tetrahydrofuran; 1,4-dioxane; methanol; ethyl methyl ether; water; trifluoroacetic acid;
7.1: Mitsunobu reaction;
DOI:10.1021/jm2001508
