5-broMo-4-Methoxy-2-MethylbenzenaMine

Base Information

• Chemical Name: 5-broMo-4-Methoxy-2-MethylbenzenaMine
• CAS No.: 861084-04-0
• Molecular Formula: C8H10BrNO
• Molecular Weight: 216.077
• Hs Code.: 2922299090
• Mol file: 861084-04-0.mol

Synonyms:5-broMo-4-Methoxy-2-MethylbenzenaMine;5-broMo-4-Methoxy-2-Methylaniline;Benzenamine, 5-bromo-4-methoxy-2-methyl-

Chemical Property of 5-broMo-4-Methoxy-2-MethylbenzenaMine

Chemical Property:

• Boiling Point: 302.1±37.0 °C(Predicted)
• PKA: 3.98±0.10(Predicted)
• PSA: 35.25000
• Density: 1.458±0.06 g/cm3 (20 ºC 760 Torr)
• LogP: 2.92950
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-Bromo-4-methoxy-2-methylaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-broMo-4-Methoxy-2-MethylbenzenaMine

There total 7 articles about 5-broMo-4-Methoxy-2-MethylbenzenaMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.5%

N-(5-bromo-4-methoxy-2-methylphenyl)acetamide → 5-bromo-4-methoxy-2-methylbenzenamine (861084-04-0)

Guidance literature:

With hydrogenchloride; In methanol; water; Reflux; Large scale;

DOI:10.1021/op400317z

Reference yield: 90.0%

1-bromo-2-methoxy-4-methyl-5-nitrobenzene (861076-28-0) → 5-bromo-4-methoxy-2-methylbenzenamine (861084-04-0)

Guidance literature:

With iron; ammonium chloride; In ethanol; water; at 80 ℃; for 1h;

DOI:10.1021/acs.jmedchem.9b00329

Reference yield:

3-methyl-4-nitrophenol (2581-34-2,910311-23-8) + methyl iodide (74-88-4) → 3-bromo-4-methoxy-2-methylaniline (29237-10-3) + 5-bromo-4-methoxy-2-methylbenzenamine (861084-04-0)

Guidance literature:

3-methyl-4-nitrophenol; With bromine; acetic acid;

methyl iodide; With potassium carbonate; In acetone; at 20 ℃; Reflux;

With triphenyl phosphite; ammonium metavanadate; hydrogen; platinum on carbon; In dichloromethane; under 4395.87 Torr;

upstream raw materials:

1-bromo-2-methoxy-4-methyl-5-nitrobenzene

3-methyl-4-nitrophenol

2-bromo-5-methyl-4-nitrophenol

methyl iodide

Downstream raw materials:

N-(3-fluoro-4-((1-methyl-6-(1H-pyrazol-4-yl)-1H-indazol-5-yl)oxy)phenyl)-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide

6-bromo-5-(2-fluoro-4-nitrophenoxy)-1H-indazole

6-bromo-5-(2-fluoro-4-nitrophenoxy)-2-methyl-2H-indazole

tert-butyl 4-(5-(2-fluoro-4-nitrophenoxy)-1-methyl-1H-indazol-6-yl)-1H-pyrazole-1-carboxylate

Refernces

• 1、 Kallman, Neil J.,Liu, Chin,Yates, Matthew H.,Linder, Ryan J.,Ruble, J. Craig,Kogut, Eugene F.,Patterson, Lawrence E.,Laird, Dana L. T.,Hansen, Marvin M.. "Route design and development of a MET kinase inhibitor: A copper-catalyzed preparation of an N 1 - Methylindazole". supporting information. p. 501 - 510. Retrieved 2014/05/06.
• 2、 -. "Glucokinase Activators". Page/Page column 109-111. . Retrieved 2009/12/05.