Spiramycin A

Base Information

• Chemical Name: Spiramycin A
• CAS No.: 8025-81-8
• Molecular Formula: C43H74N2O14
• Molecular Weight: 843.06
• Hs Code.: 29419090
• European Community (EC) Number: 232-429-6
• Wikipedia: Spiramycin
• NCI Thesaurus Code: C839
• Metabolomics Workbench ID: 149638
• Mol file: 8025-81-8.mol

Synonyms:demycarosylturimycin H;spiramycin I;Antibiotic 799;IL 5902;IL-5902;IL5902;NSC 55926;NSC 64393;NSC-55926;NSC-64393;NSC55926;NSC64393;Rovamycin;Rovamycine;Selectomycin;Spiramycin;Spiramycin Adipate;Spiramycine

Chemical Property of Spiramycin A

Chemical Property:

• Appearance/Colour: white or slightly yellowish powder
• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 126-128 °C
• Refractive Index: 81 ° (C=2, 10% AcOH)
• Boiling Point: 913.679 °C at 760 mmHg
• Flash Point: 506.375 °C
• PSA: 0.00000
• Density: 1.217 g/cm³
• LogP: 0.00000
• Storage Temp.: 2-8°C
• Solubility.: ethanol: 50 mg/mL, clear to slightly hazy, light-yellow
• Water Solubility.: Soluble in methanol. Slightly soluble in water
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 16
• Rotatable Bond Count: 11
• Exact Mass: 842.51400504
• Heavy Atom Count: 59
• Complexity: 1370

Purity/Quality:

99% ^*data from raw suppliers

Spiramycin ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-24/25

MSDS Files:

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Other Uses -> Pharmaceuticals
• Canonical SMILES: CC1CC=CC=CC(C(CC(C(C(C(CC(=O)O1)O)OC)OC2C(C(C(C(O2)C)OC3CC(C(C(O3)C)O)(C)O)N(C)C)O)CC=O)C)OC4CCC(C(O4)C)N(C)C
• Isomeric SMILES: C[C@@H]1C/C=C/C=C/[C@@H]([C@@H](C[C@@H]([C@@H]([C@H]([C@@H](CC(=O)O1)O)OC)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)C)O[C@H]3C[C@@]([C@H]([C@@H](O3)C)O)(C)O)N(C)C)O)CC=O)C)O[C@H]4CC[C@@H]([C@@H](O4)C)N(C)C
• Recent ClinicalTrials: Pyrimethamine, Sulfadiazine, and Leucovorin in Treating Patients With Congenital Toxoplasmosis
• Recent EU Clinical Trials: Essai clinique, randomisé, multicentrique comparant l’efficacité et la tolérance d’un traitement prénatal par l’association pyriméthamine et sulfadiazine vs spiramycine pour réduire la transmission verticale de Toxoplasma gondii après primo-infection de la mère pendant la grossesse
• Uses: antibacterial vitamin A Spiramycin I (foromacidin A) is the major analogue of a complex of 16-membered macrocyclic lactones produced by S. ambofaciens and S. spiramyceticus that have broad spectrum antibiotic activity. Spiramycins are unusual among the macrocyclic lactones in that they contain two basic sugars. Spiramycin complex has been used in both human and animal health but its use has not been widespread.
• Therapeutic Function: Antibacterial