5-AMinoMethyl-2-oxazolidinone

Base Information

• Chemical Name: 5-AMinoMethyl-2-oxazolidinone
• CAS No.: 119736-09-3
• Molecular Formula: C4H8N2O2
• Molecular Weight: 116.12
• Mol file: 119736-09-3.mol

Synonyms:5-AMinoMethyl-2-oxazolidinone;5-(Aminomethyl)-1,3-oxazolidin-2-one

Chemical Property of 5-AMinoMethyl-2-oxazolidinone

Chemical Property:

• Boiling Point: 382.7±11.0 °C(Predicted)
• PKA: 12.41±0.40(Predicted)
• PSA: 64.35000
• Density: 1.196±0.06 g/cm3(Predicted)
• LogP: 0.08260
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-Aminomethyl-2-oxazolidinone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Aminomethyl-2-oxazolidinone is used as an aminating agent for level dyeing or printing aminated cotton and cotton/polyester mixed textile fibers with reactive disperse dyes.

Technology Process of 5-AMinoMethyl-2-oxazolidinone

There total 3 articles about 5-AMinoMethyl-2-oxazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

S,S-dimethyl dithiocarbonate (868-84-8) + 1,3-Diamino-2-hydroxypropane (616-29-5) → tetrahydro-5-hydroxy-2(1H)-pyrimidinone (1852-18-2) + 5-(S)-aminomethyloxazolidinone (119736-09-3)

Guidance literature:

In methanol; at 60 ℃; for 24h; Yields of byproduct given;

DOI:10.1021/jo9522825

Reference yield:

5-(chloromethyl)-1,3-oxazolidin-2-one (22625-57-6) → 5-(S)-aminomethyloxazolidinone (119736-09-3)

Guidance literature:

With hydrogen; palladium; In N,N-dimethyl-formamide;

Reference yield:

5-(azidomethyl)oxazolidin-2-one (923276-78-2) → 5-(S)-aminomethyloxazolidinone (119736-09-3)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; ethyl acetate; at 20 ℃; for 12h;

DOI:10.1002/anie.201800958

upstream raw materials:

S,S-dimethyl dithiocarbonate

1,3-Diamino-2-hydroxypropane

5-(chloromethyl)-1,3-oxazolidin-2-one

5-(azidomethyl)oxazolidin-2-one

Refernces

• 1、 -. "RORγ MODULATORS". Page/Page column 47. . Retrieved 2015/03/28.
• 2、 Leung, Man-Kit,Lai, Jun-Liang,Lau, King-Hang,Yu, Hsiao-Hua,Hsiao, Hsiang-Ju. "S,S-dimethyl dithiocarbonate: A convenient reagent for the synthesis of symmetrical and unsymmetrical ureas". . p. 4175 - 4179. Retrieved 2007/10/03.