Technology Process of 5-(BROMOACETYL)THIOPHENE-2-CARBOXAMIDE
There total 9 articles about 5-(BROMOACETYL)THIOPHENE-2-CARBOXAMIDE which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
N-Bromosuccinimide; p-toluenesulfonic acid monohydrate;
In
acetonitrile;
Solvent;
Reflux;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydrogencarbonate / water / 0.5 h / 25 - 27 °C
1.2: 1 h / Reflux
2.1: ammonium hydroxide / 10 - 13 °C
3.1: acetic acid; bromine / 2 h / 80 - 95 °C
With
ammonium hydroxide; bromine; sodium hydrogencarbonate; acetic acid;
In
water;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sodium carbonate; acetic acid / methanol; water / 86 °C / pH 4 - 5
2.1: polyphosphoric acid / 100 °C
3.1: sodium hypochlorite / methanol / 10 - 70 °C
4.1: hydrogenchloride / water / 55 - 60 °C
5.1: sodium hydrogencarbonate / water / 0.5 h / 25 - 27 °C
5.2: 1 h / Reflux
6.1: ammonium hydroxide / 10 - 13 °C
7.1: acetic acid; bromine / 2 h / 80 - 95 °C
With
hydrogenchloride; ammonium hydroxide; sodium hypochlorite; bromine; sodium hydrogencarbonate; sodium carbonate; acetic acid;
In
methanol; water;