3-(3-(5-((4-METHOXYBENZYL)OXY)PYRIDIN-2-YL)-1,2,4-OXADIAZOL-5-YL)-2,2-DIMETHYLPROPANOIC ACID

Base Information

• Chemical Name: 3-(3-(5-((4-METHOXYBENZYL)OXY)PYRIDIN-2-YL)-1,2,4-OXADIAZOL-5-YL)-2,2-DIMETHYLPROPANOIC ACID
• CAS No.: 917911-01-4
• Molecular Formula: C20H21N3O5
• Molecular Weight: 383.404
• Mol file: 917911-01-4.mol

Synonyms:3-(3-(5-((4-METHOXYBENZYL)OXY)PYRIDIN-2-YL)-1,2,4-OXADIAZOL-5-YL)-2,2-DIMETHYLPROPANOIC ACID;1,2,4-Oxadiazole-5-propanoic acid, 3-[5-[(4-methoxyphenyl)methoxy]-2-pyridinyl]-α,α-dimethyl-

Chemical Property of 3-(3-(5-((4-METHOXYBENZYL)OXY)PYRIDIN-2-YL)-1,2,4-OXADIAZOL-5-YL)-2,2-DIMETHYLPROPANOIC ACID

Chemical Property:

• PSA: 107.57000
• LogP: 3.37250

Purity/Quality:

NLT 98% ^*data from raw suppliers

3-(3-(5-((4-Methoxybenzyl)oxy)pyridin-2-yl)-1,2,4-oxadiazol-5-yl)-2,2-dimethylpropanoicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(3-(5-((4-METHOXYBENZYL)OXY)PYRIDIN-2-YL)-1,2,4-OXADIAZOL-5-YL)-2,2-DIMETHYLPROPANOIC ACID

There total 1 articles about 3-(3-(5-((4-METHOXYBENZYL)OXY)PYRIDIN-2-YL)-1,2,4-OXADIAZOL-5-YL)-2,2-DIMETHYLPROPANOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C22H25N3O5 (917911-00-3) → C20H21N3O5 (917911-01-4)

Guidance literature:

With water; lithium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 2h;

DOI:10.1021/jm100022r

Reference yield:

C20H21N3O5 (917911-01-4) → C20H22N4O4 (917911-02-5)

Guidance literature:

C₂₀H₂₁N₃O₅; With 1-hydroxy-pyrrolidine-2,5-dione; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 2.5h;

With ammonia; In 1,4-dioxane; water; at 0 - 20 ℃; for 0.25h;

Reference yield:

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + C20H21N3O5 (917911-01-4) → C24H24N4O7 (1208866-75-4)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 2.5h;

DOI:10.1021/jm100022r

upstream raw materials:

C₂₂H₂₅N₃O₅

Downstream raw materials:

C₂₀H₂₂N₄O₄

C₂₄H₂₄N₄O₇

Refernces

• 1、 -. "Niacin receptor agonists, compositions containing such compounds and methods of treatment". Page/Page column 29; 49. . Retrieved 2010/11/25.