6-chloro-3-methylpicolinonitrile

Base Information

• Chemical Name: 6-chloro-3-methylpicolinonitrile
• CAS No.: 1201924-31-3
• Molecular Formula: C7H5ClN2
• Molecular Weight: 152.581
• Hs Code.: 2933399090
• Mol file: 1201924-31-3.mol

Synonyms:6-chloro-3-methylpicolinonitrile;6-Chloro-3-Methyl-pyridine-2-carbonitrile

Chemical Property of 6-chloro-3-methylpicolinonitrile

Chemical Property:

• Boiling Point: 270.5±35.0 °C(Predicted)
• PKA: -5.37±0.10(Predicted)
• PSA: 36.68000
• Density: 1.26±0.1 g/cm3(Predicted)
• LogP: 1.91508
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

6-Chloro-3-methylpicolinonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-chloro-3-methylpicolinonitrile

There total 2 articles about 6-chloro-3-methylpicolinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

3-methyl-1-oxido-pyridin-1-ium-2-carbonitrile (159727-88-5) → 6-chloro-3-methyl-pyridine-2-carbonitrile (1201924-31-3) + 4-chloro-3-methylpicolinonitrile (886372-07-2)

Guidance literature:

With trichlorophosphate; at 0 - 80 ℃; for 6h;

DOI:10.1016/j.tetlet.2020.152105

Reference yield:

2-cyano-3-methylpyridine (20970-75-6) → 6-chloro-3-methyl-pyridine-2-carbonitrile (1201924-31-3) + 4-chloro-3-methylpicolinonitrile (886372-07-2)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid; dihydrogen peroxide / water / 20 h / 90 °C

2: trichlorophosphate / 6 h / 0 - 80 °C

With dihydrogen peroxide; acetic acid; trichlorophosphate; In water;

DOI:10.1016/j.tetlet.2020.152105

Reference yield:

6-chloro-3-methyl-pyridine-2-carbonitrile (1201924-31-3) + phenylboronic acid (98-80-6) → 3-methyl-6-phenyl-pyridine-2-carbonitrile

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In toluene; at 80 ℃; for 1h;

upstream raw materials:

2-cyano-3-methylpyridine

3-methyl-1-oxido-pyridin-1-ium-2-carbonitrile

Downstream raw materials:

methyl 6-chloro-3-methyl-pyridine-2-carboxylate

6-chloro-3-methyl-pyridine-2-carboxylic acid

methyl 3-(bromomethyl)-6-chloropicolinate

2-chloro-1,7-naphthyridin-8(7H)-one

Refernces