2-BROMO-4-CHLOROPHENYLACETONITRILE

Base Information

• Chemical Name: 2-BROMO-4-CHLOROPHENYLACETONITRILE
• CAS No.: 52864-54-7
• Molecular Formula: C8H5BrClN
• Molecular Weight: 230.491
• Hs Code.: 2926907090
• Mol file: 52864-54-7.mol

Synonyms:2-BROMO-4-CHLOROPHENYLACETONITRILE;2-(2-broMo-4-chlorophenyl)acetonitrile

Chemical Property of 2-BROMO-4-CHLOROPHENYLACETONITRILE

Chemical Property:

• PSA: 23.79000
• LogP: 3.16858
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

2-(2-Bromo-4-chlorophenyl)acetonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BROMO-4-CHLOROPHENYLACETONITRILE

There total 7 articles about 2-BROMO-4-CHLOROPHENYLACETONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

potassium cyanide + 2-bromo-4-chlorobenzyl 4-methylbenzenesulphonate → 2-(2-bromo-4-chlorophenyl)acetonitrile (52864-54-7)

Guidance literature:

In acetonitrile; at 20 ℃; for 60h; Inert atmosphere;

Reference yield:

sodium cyanide (773837-37-9) + 2-bromo-4-chlorobenzyl bromide (33924-45-7) → 2-(2-bromo-4-chlorophenyl)acetonitrile (52864-54-7)

Guidance literature:

In ethanol; water; for 0.5h; Reflux;

Reference yield:

(2-bromo-4-chloro-phenyl)methanol (143888-84-0) → 2-(2-bromo-4-chlorophenyl)acetonitrile (52864-54-7)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide / tetrahydrofuran / 20 °C / Inert atmosphere; Cooling with ice

2: acetonitrile / 60 h / 20 °C / Inert atmosphere

With potassium hydroxide; In tetrahydrofuran; acetonitrile;

upstream raw materials:

2-bromo-4-chlorobenzyl bromide

sodium cyanide

sodium cyanide

(2-bromo-4-chloro-phenyl)methanol

Downstream raw materials:

2-(4-chloro-2-methoxyphenyl)ethanamine

Refernces

• 1、 Karad, Somnath Narayan,Liu, Rai-Shung. "Gold-catalyzed 1,2-oxoarylations of nitriles with pyridine-derived oxides". supporting information. p. 5444 - 5448. Retrieved 2014/06/09.
• 2、 Petigara,Yale. "Novel polycyclic heterocycles. XI. Synthesis of 11,12 dihydropyrido [2,1 b] [1,3] benzodiazepines, 6h pyrido[1,2 c] [1,3,5] benzoxadiazepines, and 6h pyrido[1,2 c] [1,3,5]benzothiadiazepines (1)". . p. 331 - 337. Retrieved 2007/10/04.