Thiazolo[4,5-f]quinoline, 2-methyl- (9CI)

Base Information

• Chemical Name: Thiazolo[4,5-f]quinoline, 2-methyl- (9CI)
• CAS No.: 38463-33-1
• Molecular Formula: C₁₁H₈N₂S
• Molecular Weight: 200.264
• Mol file: 38463-33-1.mol

Synonyms:Thiazolo[4,5-f]quinoline, 2-methyl- (9CI);2-Methylthiazolo[4,5-f]quinoline

Chemical Property of Thiazolo[4,5-f]quinoline, 2-methyl- (9CI)

Chemical Property:

Purity/Quality:

2-METHYLTHIAZOLO[4,5-F]QUINOLINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Thiazolo[4,5-f]quinoline, 2-methyl- (9CI)

There total 5 articles about Thiazolo[4,5-f]quinoline, 2-methyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

5-thioacetamidoquinoline (404850-19-7) → 2-Methylthiazolochinolin (38463-33-1)

Guidance literature:

With K₃Fe(CN)6; In sodium hydroxide; water; at 20 ℃; for 1h;

DOI:10.3998/ark.5550190.0011.b22

Reference yield:

2-methyl-5-aminobenzothiazole (13382-43-9) + glycerol (56-81-5,25618-55-7,64333-26-2,8013-25-0) → 2-Methylthiazolochinolin (38463-33-1)

Guidance literature:

With arsenic(V) oxide; sulfuric acid; at 160 - 170 ℃;

Reference yield:

2-methyl-5-nitrobenzothiazole (2941-66-4) → 2-Methylthiazolochinolin (38463-33-1)

Guidance literature:

Multi-step reaction with 2 steps

1: tin; aqueous HCl

2: concentrated H₂SO₄; as2O₅ / 160 - 170 °C

With hydrogenchloride; tin; arsenic(V) oxide; sulfuric acid;

upstream raw materials:

2-methyl-5-aminobenzothiazole

glycerol

sulfuric acid

2-methyl-5-nitrobenzothiazole

Refernces