RITONAVIR-D6

Base Information

• Chemical Name: RITONAVIR-D6
• CAS No.: 1217720-20-1
• Molecular Formula: C37H42D6N6O5S2
• Molecular Weight: 726.98
• Mol file: 1217720-20-1.mol

Synonyms:RITONAVIR-D6;(3S,4S,6S,9S)-4-Hydroxy-12-methyl-9-(1-methylethyl-d6)-13-[2-(1-methylethyl)-4-thiazolyl]-8,11-dioxo-3,6-bis(phenylmethyl)-2,7,10,12-tetraazatridecanoic Acid 5-thiazolylmethyl Ester;A 84538-d6;ABT 538-d6;Norvir-d;Norvir-d6

Chemical Property of RITONAVIR-D6

Chemical Property:

• Storage Temp.: -20°C Freezer, Under Inert Atmosphere
• Solubility.: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

98% ^*data from raw suppliers

Ritonavir-d6 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: A deuterated selective HIV protease inhibitor Ritonavir (R535000). (Ritonavir-d6) Labeled Ritonavir, intended for use as an internal standard for the quantification of Ritonavir by GC- or LC-mass spectrometry. A deuterated selective HIV protease inhibitor Ritonavir (R535000). It is a COVID19-related research product.

Technology Process of RITONAVIR-D6

There total 5 articles about RITONAVIR-D6 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C14H17(2)H6N3O3S + (2S,3S,5S)-5-Amino-2-(N-((5-thiazolyl)-methoxycarbonyl)amino)-3-hydroxy-1,6-diphenylhexane (144164-11-4) → C37H42(2)H6N6O5S2 (1217720-20-1)

Guidance literature:

C₁₄H₁₇⁽²⁾H₆N₃O₃S; With 4-methyl-morpholine; isobutyl chloroformate; In tetrahydrofuran; at -10 ℃; for 2h; Inert atmosphere;

(2S,3S,5S)-5-Amino-2-(N-((5-thiazolyl)-methoxycarbonyl)amino)-3-hydroxy-1,6-diphenylhexane; In tetrahydrofuran; at -10 - 25 ℃; for 6h; Inert atmosphere;

Reference yield:

C7H4(2)H6ClNS → C37H42(2)H6N6O5S2 (1217720-20-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: ethanol / 3 h / 25 °C

2.1: dmap; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 6 h / 80 °C

3.1: sodium hydroxide; water / methanol / 4 h / 25 °C

4.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 2 h / -10 °C / Inert atmosphere

4.2: 6 h / -10 - 25 °C / Inert atmosphere

With 4-methyl-morpholine; dmap; water; N-ethyl-N,N-diisopropylamine; sodium hydroxide; isobutyl chloroformate; In tetrahydrofuran; methanol; ethanol;

Reference yield:

C8H8(2)H6N2S → C37H42(2)H6N6O5S2 (1217720-20-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: dmap; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 6 h / 80 °C

2.1: sodium hydroxide; water / methanol / 4 h / 25 °C

3.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 2 h / -10 °C / Inert atmosphere

3.2: 6 h / -10 - 25 °C / Inert atmosphere

With 4-methyl-morpholine; dmap; water; N-ethyl-N,N-diisopropylamine; sodium hydroxide; isobutyl chloroformate; In tetrahydrofuran; methanol;

upstream raw materials:

(2S,3S,5S)-5-Amino-2-(N-((5-thiazolyl)-methoxycarbonyl)amino)-3-hydroxy-1,6-diphenylhexane

Refernces