2-AMino-2-(4-broMophenyl)acetic acid

Base Information

• Chemical Name: 2-AMino-2-(4-broMophenyl)acetic acid
• CAS No.: 119397-06-7
• Molecular Formula: C₈H₈BrNO₂
• Molecular Weight: 230.061
• Hs Code.: 2922498590
• Mol file: 119397-06-7.mol

Synonyms:4-BroMo-DL-phenylglycine, 95%

Chemical Property of 2-AMino-2-(4-broMophenyl)acetic acid

Chemical Property:

• Melting Point: 273-274℃
• PSA: 63.32000
• LogP: 2.23380

Purity/Quality:

98%min ^*data from raw suppliers

2-Amino-2-(4-bromophenyl)aceticAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMino-2-(4-broMophenyl)acetic acid

There total 13 articles about 2-AMino-2-(4-broMophenyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

4-bromophenylglyoxylic acid (7099-87-8) → 2-amino-2-(4-bromophenyl)acetic acid (119397-06-7,71079-03-3)

Guidance literature:

With (S)-2-amino-(2-chlorophenyl)ethanoic acid; In water; acetonitrile; at 50 ℃; for 36h; Reflux; Inert atmosphere;

DOI:10.1021/acs.joc.0c01302

Reference yield:

1-(4-Bromophenyl)imidazolidine-2,4-dione (32549-34-1) → 2-amino-2-(4-bromophenyl)acetic acid (119397-06-7,71079-03-3)

Guidance literature:

1-(4-Bromophenyl)imidazolidine-2,4-dione; With sodium hydroxide; In water; at 101 - 175 ℃; under 3750.38 - 7500.75 Torr; Large scale;

With sulfuric acid; In water; at 35 - 100 ℃; pH=5.5-6; Large scale;

Reference yield:

sodium cyanide (773837-37-9) + 4-bromo-benzaldehyde (1122-91-4) → 2-amino-2-(4-bromophenyl)acetic acid (119397-06-7,71079-03-3)

Guidance literature:

sodium cyanide; 4-bromo-benzaldehyde; With ammonium chloride; In methanol; water; at 20 ℃; for 24.3333h;

With hydrogenchloride; water; for 72h; Reflux;

DOI:10.1016/j.tet.2011.04.064

upstream raw materials:

phenylglycin

1-bromo-4-(1-bromo-1-methoxycarbonyl)toluene

sodium cyanide

4-bromo-benzaldehyde

Downstream raw materials:

methyl 2-amino-2-(4-bromophenyl)acetate hydrochloride

methyl 6-bromo-(1H)-isoindolin-1-one-3-carboxylate

tert-butyl (1-(4-bromophenyl)-2-hydroxyethyl)carbamate

Refernces

• 1、 Inada, Haruki,Shibuya, Masatoshi,Yamamoto, Yoshihiko. "Synthesis of Unprotected 2-Arylglycines by Transamination of Arylglyoxylic Acids with 2-(2-Chlorophenyl)glycine". . p. 11047 - 11059. Retrieved 2020/10/12.
• 2、 Zhou, Yi,Wu, Shuke,Li, Zhi. "One-Pot Enantioselective Synthesis of d-Phenylglycines from Racemic Mandelic Acids, Styrenes, or Biobased l-Phenylalanine via Cascade Biocatalysis". supporting information. p. 4305 - 4316. Retrieved 2017/11/21.