2-BroMo-4-(1,3-dioxoisoindolin-2-yl)butanoic acid

Base Information

• Chemical Name: 2-BroMo-4-(1,3-dioxoisoindolin-2-yl)butanoic acid
• CAS No.: 35197-64-9
• Molecular Formula: C12H10BrNO4
• Molecular Weight: 312.12
• Hs Code.: 2925190090
• Mol file: 35197-64-9.mol

Synonyms:2-BroMo-4-(1,3-dioxoisoindolin-2-yl)butanoic acid;2-Bromo-4-(1,3-dioxoisoindolin-2-yl)

Chemical Property of 2-BroMo-4-(1,3-dioxoisoindolin-2-yl)butanoic acid

Chemical Property:

• PSA: 74.68000
• LogP: 1.45870
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2-Bromo-4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butanoic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BroMo-4-(1,3-dioxoisoindolin-2-yl)butanoic acid

There total 7 articles about 2-BroMo-4-(1,3-dioxoisoindolin-2-yl)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-phthalimidobutyric acid (3130-75-4) → 2-bromo-4-(1,3-dioxoisoindolin-2-yl)butanoic acid (35197-64-9)

Guidance literature:

With phosphorus; bromine; In tetrachloromethane; Heating; 6-8 h;

DOI:10.1021/jo00301a008

Reference yield:

N-ethoxycarbonylphthalimide (22509-74-6) → 2-bromo-4-(1,3-dioxoisoindolin-2-yl)butanoic acid (35197-64-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 36 percent / Na₂CO₃ / H₂O / 6 h

2: 80 percent / Br₂, red P / CCl₄ / 80 deg C, 30 min, reflux 8 h

With phosphorus; bromine; sodium carbonate; In tetrachloromethane; water;

DOI:10.1248/cpb.34.2078

Reference yield:

phthalic anhydride (85-44-9) → 2-bromo-4-(1,3-dioxoisoindolin-2-yl)butanoic acid (35197-64-9)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / toluene / 18 h / 110 °C

2: bromine; phosphorus / tetrachloromethane / 9 h / 60 °C

With phosphorus; bromine; triethylamine; In tetrachloromethane; toluene;

upstream raw materials:

4-phthalimidobutyric acid

2-amino-4-phthalimido-butyric acid

N-ethoxycarbonylphthalimide

phthalic anhydride

Downstream raw materials:

2-bromo-4-(1,3-dioxoisoindolin-2-yl)-N-(4-methylbenzyl)butanamide

2-bromo-4-(1,3-dioxoisoindolin-2-yl)-N-(4-fluorobenzyl)butanamide

2-bromo-N-(4-chlorobenzyl)-4-(1,3-dioxoisoindolin-2-yl)butanamide

2-bromo-N-(2-chlorobenzyl)-4-(1,3-dioxoisoindolin-2-yl)butanamide

Refernces

• 1、 Coxon, Fraser,Joachimiak, ?ukasz,Najumudeen, Arafath Kaja,Breen, George,Gmach, Joanna,Oetken-Lindholm, Christina,Way, Rebecca,Dunford, James,Abankwa, Daniel,B?azewska, Katarzyna M.. "Synthesis and characterization of novel phosphonocarboxylate inhibitors of RGGT". supporting information. p. 77 - 89. Retrieved 2014/07/22.
• 2、 -. "INHIBITORS OF CHECKPOINT KINASES". Page/Page column 63. . Retrieved 2009/10/09.