tert-butyl isothiazol-3-ylcarbaMate

Base Information

• Chemical Name: tert-butyl isothiazol-3-ylcarbaMate
• CAS No.: 72592-18-8
• Molecular Formula: C₈H₁₂N₂O₂S
• Molecular Weight: 200.261
• Mol file: 72592-18-8.mol

Synonyms:tert-butyl isothiazol-3-ylcarbaMate

Chemical Property of tert-butyl isothiazol-3-ylcarbaMate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl isothiazol-3-ylcarbaMate

There total 1 articles about tert-butyl isothiazol-3-ylcarbaMate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

3-isothiazolecarboxylic acid (4576-90-3) + tert-butyl alcohol (75-65-0) → tert-butyl isothiazol-3-ylcarbamate (72592-18-8)

Guidance literature:

With diphenyl phosphoryl azide; triethylamine; for 9h; Reflux;

Reference yield:

tert-butyl isothiazol-3-ylcarbamate (72592-18-8) → tert-butyl (S)-((4-((1-benzylpyrrolidin-3-yl)amino)-5-chloro-2-fluorophenyl)sulfonyl)(isothiazol-3-yl)carbamate

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1.17 h / -78 - 20 °C

1.2: 12 h / -78 - 20 °C

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 50 °C

With N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

tert-butyl isothiazol-3-ylcarbamate (72592-18-8) → tert-butyl ((4-((2-(azetidin-1-ylmethyl)-6-fluorobenzyl)amino)-3-bromo-2,6-difluorophenyl)sulfonyl)(isothiazol-3-yl)carbamate

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1.17 h / -78 - 20 °C

1.2: 12 h / -78 - 20 °C

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 °C

With N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide;

upstream raw materials:

3-isothiazolecarboxylic acid

tert-butyl alcohol

Refernces

• 1、 -. "HETEROARYL-SUBSTITUTED SULFONAMIDE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS". Page/Page column 106-107. . Retrieved 2020/03/23.
• 2、 -. "BENZENESULFONAMIDE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS". Page/Page column 343-344. . Retrieved 2017/12/18.