NIMODIPINE RELATED COMPOUND B (50 MG) (BIS(2-METHOXYETHYL) 2,6-DIMETHYL-4-(3-NITROPHE-NYL)-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLATE) (AS)

Base Information

• Chemical Name: NIMODIPINE RELATED COMPOUND B (50 MG) (BIS(2-METHOXYETHYL) 2,6-DIMETHYL-4-(3-NITROPHE-NYL)-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLATE) (AS)
• CAS No.: 70172-96-2
• Molecular Formula: C21H26N2O8
• Molecular Weight: 434.43974
• Hs Code.: 2933399090
• Mol file: 70172-96-2.mol

Synonyms:NIMODIPINE RELATED COMPOUND B (50 MG) (BIS(2-METHOXYETHYL) 2,6-DIMETHYL-4-(3-NITROPHE-NYL)-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLATE) (AS);Nimodipine Related Compound B (50 mg) (bis(2-methoxyethyl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate);1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid bis(2-methoxyethyl) ester;Nimodipine impurity B;(RS)-Di-2-methoxyethyl-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate;Nimodipine EP Impurity C

Chemical Property of NIMODIPINE RELATED COMPOUND B (50 MG) (BIS(2-METHOXYETHYL) 2,6-DIMETHYL-4-(3-NITROPHE-NYL)-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLATE) (AS)

Chemical Property:

• Melting Point: 130℃
• Boiling Point: 557.5±50.0 °C(Predicted)
• PKA: 2.60±0.70(Predicted)
• PSA: 128.91000
• Density: 1.237±0.06 g/cm3(Predicted)
• LogP: 3.06080
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

O-Desisopropyl-O-methoxyethylNimodipine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: O-Desisopropyl-O-methoxyethyl Nimodipine (Nimodipine EP Impurity C) is an impurity in the synthesis of Nimodipine (A dihydropyridine calcium channel blocker. It is used as a vasodilator (cerebral). Nimodipine USP Related Compound B.

Technology Process of NIMODIPINE RELATED COMPOUND B (50 MG) (BIS(2-METHOXYETHYL) 2,6-DIMETHYL-4-(3-NITROPHE-NYL)-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLATE) (AS)

There total 3 articles about NIMODIPINE RELATED COMPOUND B (50 MG) (BIS(2-METHOXYETHYL) 2,6-DIMETHYL-4-(3-NITROPHE-NYL)-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLATE) (AS) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-methoxyethyl-3-oxobutanoate (22502-03-0) + 3-nitro-benzaldehyde (99-61-6) → bis(2-methoxyethyl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate (70172-96-2)

Guidance literature:

With ammonium acetate; Darkness; Reflux;

DOI:10.1248/cpb.c17-00186

Reference yield:

2-methoxy-ethanol (109-86-4,95507-80-5) + nimodipin (66085-59-4) → bis(2-methoxyethyl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate (70172-96-2)

Guidance literature:

With hydrogenchloride; at 70 - 80 ℃; Darkness;

Reference yield:

→ bis(2-methoxyethyl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate (70172-96-2)

Guidance literature:

Aus Acetessigsaeure-2-methoxyethylester + 3-Nitrobenzaldehyd + NH3;

upstream raw materials:

2-methoxy-ethanol

nimodipin

2-methoxyethyl-3-oxobutanoate

3-nitro-benzaldehyde

Refernces

• 1、 El-Moselhy, Tarek Fathy,Sidhom, Peter Ayoub,Esmat, Eman Ahmed,El-Mahdy, Nageh Ahmed. "Synthesis, docking simulation, biological evaluations and 3D-QSAR study of 1,4-dihydropyridines as calcium channel blockers". . p. 893 - 903. Retrieved 2018/10/31.