Methyl 2-chloro-5-(trifluoroMethyl)nicotinate

Base Information

• Chemical Name: Methyl 2-chloro-5-(trifluoroMethyl)nicotinate
• CAS No.: 1360934-51-5
• Molecular Formula: C8H5ClF3NO2
• Molecular Weight: 239.581
• Hs Code.: 2933399090
• Mol file: 1360934-51-5.mol

Synonyms:Methyl 2-chloro-5-(trifluoroMethyl)nicotinate;2-Chloro-5-trifluoromethyl-nicotinic acid methyl ester

Chemical Property of Methyl 2-chloro-5-(trifluoroMethyl)nicotinate

Chemical Property:

• Boiling Point: 254.1±40.0 °C(Predicted)
• PKA: -4.10±0.10(Predicted)
• PSA: 39.19000
• Density: 1.443±0.06 g/cm3(Predicted)
• LogP: 2.54040
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

NLT 98% ^*data from raw suppliers

Methyl2-chloro-5-(trifluoromethyl)nicotinate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 2-chloro-5-(trifluoroMethyl)nicotinate

There total 4 articles about Methyl 2-chloro-5-(trifluoroMethyl)nicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-5-(trifluoromethyl)pyridine-3-carboxylic acid (505084-59-3) + diazomethyl-trimethyl-silane (18107-18-1) → methyl 2-chloro-5-(trifluoromethyl)pyridine-3-carboxylate (1360934-51-5)

Guidance literature:

With methanol; In diethyl ether; at -20 - 20 ℃; for 1h;

Reference yield:

2-chloro-5-(trifluoromethyl)pyridine-3-carboxylic acid (505084-59-3) + methyl iodide (74-88-4) → methyl 2-chloro-5-(trifluoromethyl)pyridine-3-carboxylate (1360934-51-5)

Guidance literature:

2-chloro-5-(trifluoromethyl)pyridine-3-carboxylic acid; With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.0833333h;

methyl iodide; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

methanol (67-56-1) + 2-chloro-5-(trifluoromethyl)pyridine-3-carboxylic acid (505084-59-3) → methyl 2-chloro-5-(trifluoromethyl)pyridine-3-carboxylate (1360934-51-5)

Guidance literature:

2-chloro-5-(trifluoromethyl)pyridine-3-carboxylic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; for 1h; Cooling with ice;

methanol; With triethylamine; In tetrahydrofuran; Cooling with ice;

upstream raw materials:

methanol

2-chloro-5-(trifluoromethyl)pyridine-3-carboxylic acid

diazomethyl-trimethyl-silane

methyl iodide

Refernces

• 1、 -. "PESTICIDALLY ACTIVE HETEROCYCLIC DERIVATIVES WITH SULFUR CONTAINING SUBSTITUENTS". Page/Page column 120. . Retrieved 2020/09/12.
• 2、 -. "NOVEL SUBSTITUTED BIARYL COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE (IDO) INHIBITORS". Paragraph 1194; 1195. . Retrieved 2019/05/24.