Technology Process of tert-butyl 3-(5-amino-6-(dibenzylamino)pyrimidin-4-ylamino)phenyl(methyl)carbamate
There total 8 articles about tert-butyl 3-(5-amino-6-(dibenzylamino)pyrimidin-4-ylamino)phenyl(methyl)carbamate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
iron; ammonium chloride;
In
tetrahydrofuran; methanol; water;
at 50 ℃;
for 5h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C
1.2: 2 h / 20 °C
2.1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran; methanol
3.1: triethylamine / 1,4-dioxane / 60 °C
4.1: ammonium chloride; iron / water; tetrahydrofuran; methanol / 5 h / 50 °C / Inert atmosphere
With
palladium 10% on activated carbon; hydrogen; iron; sodium hydride; ammonium chloride; triethylamine;
In
tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; mineral oil;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: triethylamine; dmap / dichloromethane; ethyl acetate; Petroleum ether / 3 h / 20 °C
2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C
2.2: 2 h / 20 °C
3.1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran; methanol
4.1: triethylamine / 1,4-dioxane / 60 °C
5.1: ammonium chloride; iron / water; tetrahydrofuran; methanol / 5 h / 50 °C / Inert atmosphere
With
dmap; palladium 10% on activated carbon; hydrogen; iron; sodium hydride; ammonium chloride; triethylamine;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; mineral oil; Petroleum ether;