R-Clopidogrel carboxylic acid

Base Information

• Chemical Name: R-Clopidogrel carboxylic acid
• CAS No.: 324757-50-8
• Molecular Formula: C15H14ClNO2S
• Molecular Weight: 307.801
• Hs Code.: 2934999090
• UNII: N8GXZ27ZHW
• Nikkaji Number: J1.485.221B
• Mol file: 324757-50-8.mol

Synonyms:R-CLOPIDOGREL CARBOXYLIC ACID;324757-50-8;N8GXZ27ZHW;Clopidogrel carboxylic acid, (R)-;UNII-N8GXZ27ZHW;(R)-Clopidogrel carboxylic acid [USP-RS];(2R)-2-(2-chlorophenyl)-2-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetic acid;(alphaR)-alpha-(2-Chlorophenyl)-6,7-dihydrothieno(3,2-C)pyridine-5(4H)-acetic acid;(R)-2-(2-Chlorophenyl)-2-(6,7-dihydrothieno(3,2-C)pyridin-5(4H)-yl)acetic acid;Thieno(3,2-C)pyridine-5(4H)-acetic acid, alpha-(2-chlorophenyl)-6,7-dihydro-, (alphaR)-;(alphaR)-alpha-(2-Chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetic acid;(R)-2-(2-Chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetic acid;Thieno[3,2-c]pyridine-5(4H)-acetic acid, alpha-(2-chlorophenyl)-6,7-dihydro-, (alphaR)-;SCHEMBL3173500;AKOS030242288;CS-0165218;J-018751;(R)-a-(2-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetic acid;Thieno[3,2-c]pyridine-5(4H)-acetic acid, |A-(2-chlorophenyl)-6,7-dihydro-, (|AR)-;(R)-2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetic acid? (Clopidogrel Impurity pound(c)

Chemical Property of R-Clopidogrel carboxylic acid

Chemical Property:

• Melting Point: 84-90°C
• Boiling Point: 447.3±45.0 °C(Predicted)
• PKA: 1.61±0.10(Predicted)
• PSA: 68.78000
• Density: 1.405±0.06 g/cm3(Predicted)
• LogP: 3.52340
• Storage Temp.: -20°C Freezer
• Solubility.: Methanol (Slightly), Water (Slightly)
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 307.0433776
• Heavy Atom Count: 20
• Complexity: 368

Purity/Quality:

99.90% ^*data from raw suppliers

R-ClopidogrelCarboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN(CC2=C1SC=C2)C(C3=CC=CC=C3Cl)C(=O)O
• Isomeric SMILES: C1CN(CC2=C1SC=C2)[C@H](C3=CC=CC=C3Cl)C(=O)O
• Uses: An optically active metabolite of the drug Clopidogrel. An optically active metabolite of the drug Clopidogrel

Technology Process of R-Clopidogrel carboxylic acid

There total 1 articles about R-Clopidogrel carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridine-5(4H)-yl)acetic acid (90055-55-3) + cinchonine (118-10-5,485-70-1,485-71-2,550-54-9,40134-63-2,72402-55-2,72402-56-3) → C15H14ClNO2S*C19H22N2O (1007128-30-4) + clopidogrel carboxylate (324757-50-8)

Guidance literature:

In ethanol; acetone; at 20 ℃; for 18h; Purification / work up; Resolution of racemate;

Reference yield: 98.4%

clopidogrel carboxylate (324757-50-8) → 2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridine-5(4H)-yl)acetic acid (90055-55-3)

Guidance literature:

clopidogrel carboxylate; With sodium hydroxide; In water; for 18h;

With acetic acid; In water; pH=4 - 5;

upstream raw materials:

2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridine-5(4H)-yl)acetic acid

cinchonine

Downstream raw materials:

2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridine-5(4H)-yl)acetic acid

Refernces