[[[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxyphosphonic acid

Base Information

• Chemical Name: [[[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxyphosphonic acid
• CAS No.: 4468-22-8
• Molecular Formula: C10H16N5O13P3
• Molecular Weight: 508.1812
• Mol file: 4468-22-8.mol

Synonyms:

Chemical Property of [[[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxyphosphonic acid

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Density: 2.63g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of [[[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxyphosphonic acid

There total 2 articles about [[[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxyphosphonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

[32P]-adenosine-5'-phosphate (3768-35-2) → [α-32P] ATP (4468-22-8,4622-69-9)

Guidance literature:

With piruvate kinase; T₅ bacteriophage deoxynucleoside monophosphate kinase; potassium chloride; dATP; magnesium chloride; diothiothreitol; at 37 ℃; for 0.5h; pH=8; Tris-HCl buffer; Enzymatic reaction;

DOI:10.1134/S1068162009060090

Reference yield:

→ [α-32P] ATP (4468-22-8,4622-69-9)

Guidance literature:

32P-Adenosin-5'-monophosphat, 1.)->32P-Adenosin-5'-morpholinophosphat, 2.)Pyrophosphat, wasserfr.DMSO;

DOI:10.1021/ja01060a066

Reference yield:

Zidovudine triphosphate (92586-35-1) + [α-32P] ATP (4468-22-8,4622-69-9) → C20H28N10O19P2(32)P2 + C20H28N10O19P3(32)P

Guidance literature:

With Escherichia coli inorganic pyrophosphatase; tris hydrochloride; In water; at 37 ℃; for 0.25h; pH=7.8;

DOI:10.1007/s11171-005-0077-6

upstream raw materials:

[32P]-adenosine-5'-phosphate

Refernces