Biphenyl-3-YL(phenyl)methanone

Base Information

• Chemical Name: Biphenyl-3-YL(phenyl)methanone
• CAS No.: 3378-09-4
• Molecular Formula: C19H14O
• Molecular Weight: 258.32
• Hs Code.: 2914399090
• DSSTox Substance ID: DTXSID50453128
• Nikkaji Number: J734.888F
• Wikidata: Q82274155
• Mol file: 3378-09-4.mol

Synonyms:BIPHENYL-3-YL(PHENYL)METHANONE;3378-09-4;Phenyl-(3-phenylphenyl)methanone;[1,1'-biphenyl]-3-yl(phenyl)methanone;m-Phenylbenzophenon;3-Phenylbenzophenone;3-Biphenylyl(phenyl)methanone;SCHEMBL11183749;DTXSID50453128;MFCD09055168;AKOS015958973;BS-37862;F87914;{[1,1'-BIPHENYL]-3-YL}(PHENYL)METHANONE

Chemical Property of Biphenyl-3-YL(phenyl)methanone

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 434.209°C at 760 mmHg
• Flash Point: 191.893°C
• PSA: 17.07000
• Density: 1.109g/cm³
• LogP: 4.58460
• XLogP3: 5.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 258.104465066
• Heavy Atom Count: 20
• Complexity: 310

Purity/Quality:

99% ^*data from raw suppliers

[1,1'-Biphenyl]-3-yl(phenyl)methanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=CC(=CC=C2)C(=O)C3=CC=CC=C3

Technology Process of Biphenyl-3-YL(phenyl)methanone

There total 14 articles about Biphenyl-3-YL(phenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

3-bromobenzophenone (1016-77-9) + phenylboronic acid (98-80-6) → (biphenyl-3-yl)(phenyl)methanone (3378-09-4)

Guidance literature:

With dichloro{1-(2-(bis(3,5-dimethylphenyl)phosphinyl)phenyl)-N-phenylmethanimine}-palladium(II); potassium carbonate; In water; N,N-dimethyl-formamide; at 80 ℃; for 12h; Reagent/catalyst; Schlenk technique; Inert atmosphere;

DOI:10.1016/j.ica.2018.06.013

Reference yield: 88.0%

3-chlorobenzophenone (1016-78-0) + phenylboronic acid (98-80-6) → (biphenyl-3-yl)(phenyl)methanone (3378-09-4)

Guidance literature:

With tetrakis(triphenylphosphine)nickel⁽⁰⁾;

DOI:10.1021/ol0159219

Reference yield: 85.0%

3-Biphenylboronic acid (5122-95-2) + 1-(benzoyl)piperidine-2,6-dione → (biphenyl-3-yl)(phenyl)methanone (3378-09-4)

Guidance literature:

With palladium diacetate; potassium carbonate; tricyclohexylphosphine tetrafluoroborate; In neat (no solvent); for 0.166667h; chemoselective reaction; Milling;

DOI:10.1002/anie.202114146

upstream raw materials:

[(1,1'-biphenyl)-3-yl]magnesium bromide

benzonitrile

3-bromobiphenyl

benzophenone

Downstream raw materials:

(+/-)-Hydroxy-phenyl-(biphenylyl-⁽³⁾)-methan

Refernces

• 1、 Ma, Yangmin,Shao, Lei,Szostak, Michal,Wang, Ruihong,Zhang, Jin,Zhang, Pei. "Mechanochemical Solvent-Free Suzuki–Miyaura Cross-Coupling of Amides via Highly Chemoselective N?C Cleavage". . . Retrieved 2022/01/04.
• 2、 Bagherzadeh, Nastaran,Sardarian, Ali Reza,Eslahi, Hassan. "Sustainable and recyclable magnetic nanocatalyst of 1,10-phenanthroline Pd(0) complex in green synthesis of biaryls and tetrazoles using arylboronic acids as versatile substrates". . . Retrieved 2021/04/02.