7β-Hydroxy Cholesterol 3β-Acetate

Base Information

• Chemical Name: 7β-Hydroxy Cholesterol 3β-Acetate
• CAS No.: 17974-77-5
• Molecular Formula: C29H48O3
• Molecular Weight: 444.698
• Mol file: 17974-77-5.mol

Synonyms:7β-Hydroxy Cholesterol 3β-Acetate;7β-Hydroxycholesteryl 3β-Acetate

Chemical Property of 7β-Hydroxy Cholesterol 3β-Acetate

Chemical Property:

• PSA: 46.53000
• LogP: 6.93030
• Solubility.: Dichloromethane, Ethyl Acetate

Purity/Quality:

97% ^*data from raw suppliers

7β-HydroxyCholesterol3β-Acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Intermediate in the preparation of Cholesterol metabolites.

Technology Process of 7β-Hydroxy Cholesterol 3β-Acetate

There total 46 articles about 7β-Hydroxy Cholesterol 3β-Acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

Cholesteryl acetate (604-35-3) → 3β-acetoxy-7β-hydroxycholest-5-ene (17974-77-5) + 7-ketocholesteryl acetate (809-51-8)

Guidance literature:

With tert.-butylhydroperoxide; tetra-(n-butyl)ammonium iodide; In dichloromethane; at 23 ℃; for 48h; chemoselective reaction;

DOI:10.1002/asia.201800256

Reference yield: 40.0%

Cholesteryl acetate (604-35-3) → 7α-hydroxycholest-5-en-3β-yl 3-acetate (19317-90-9) + 3β-acetoxy-7β-hydroxycholest-5-ene (17974-77-5) + 7-ketocholesteryl acetate (809-51-8) + 5,6-β-epoxycholesteryl acetate (1256-31-1)

Guidance literature:

With ferric picolinate complexes; dihydrogen peroxide; In acetonitrile; for 3h; Further byproducts given; Ambient temperature;

DOI:10.1248/cpb.45.750

Reference yield: 40.0%

7α-nitroaminocholest-5-en-3β-yl acetate (82423-54-9) → 7α-hydroxycholest-5-en-3β-yl 3-acetate (19317-90-9) + 3β-acetoxy-7β-hydroxycholest-5-ene (17974-77-5) + 7-ketocholesteryl acetate (809-51-8)

Guidance literature:

at 160 ℃; for 1h; Title compound not separated from byproducts;

upstream raw materials:

pyridine

cholest-5-en-3β,7β-diol

acetic anhydride

7-ketocholesteryl acetate

Downstream raw materials:

7-ketocholesteryl acetate

7β-hydroxy-5β,6β-epoxycholestan-3β-yl acetate

7-dehydrocholesterol

7-Dehydrocholesteryl acetate

Refernces

• 1、 Poza, Jesus Javier,Jimenez, Carlos,Rodriguez, Jaime. "J-based analysis and DFT-NMR assignments of natural complex molecules: Application to 3β,7-dihydroxy-5,6-epoxycholestanes". . p. 3960 - 3969. Retrieved 2008.
• 2、 Gao, Junlan,Yue, Qiulin,Ji, Yishun,Cheng, Beijiu,Zhang, Xin. "Novel synthesis strategy for the preparation of individual phytosterol oxides". . p. 982 - 988. Retrieved 2013.
• 3、 -. "NANOEMULSIONS AND METHODS FOR CANCER THERAPY". . . Retrieved 2017/12/15.