Technology Process of 3-METHOXY-(3BETA)-OLEAN-12-EN-28-OIC ACID METHYL ESTER
There total 1 articles about 3-METHOXY-(3BETA)-OLEAN-12-EN-28-OIC ACID METHYL ESTER which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Oleanolic acid;
With
sodium hydride;
In
tetrahydrofuran;
at 25 ℃;
for 0.25h;
methyl iodide;
for 24h;
Reflux;
Inert atmosphere;
DOI:10.2174/1573406414666180222094544
- Guidance literature:
-
Multi-step reaction with 3 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 24 h / -12 - 20 °C / Inert atmosphere
2: triphenylphosphine; carbon tetrabromide / acetonitrile / 7 h / 90 °C
3: lithium aluminium tetrahydride / tetrahydrofuran / 22 h / -12 - 20 °C / Reflux; Inert atmosphere
With
lithium aluminium tetrahydride; carbon tetrabromide; triphenylphosphine;
In
tetrahydrofuran; acetonitrile;
DOI:10.2174/1573406414666180222094544
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 20 °C / Reflux
2.1: pyridine; trifluoromethylsulfonic anhydride / dichloromethane / 1 h / Inert atmosphere; Cooling
2.2: 4 h / 60 °C
3.1: copper(ll) sulfate pentahydrate; sodium L-ascorbate / methanol; water / 12 h / 20 °C
With
pyridine; lithium aluminium tetrahydride; copper(ll) sulfate pentahydrate; trifluoromethylsulfonic anhydride; sodium L-ascorbate;
In
tetrahydrofuran; methanol; dichloromethane; water;
