2-(4-(DifluoroMethyl)phenyl)-4,4,5,5-tetraMethyl-1,3,2-dioxaborolane

Base Information

• Chemical Name: 2-(4-(DifluoroMethyl)phenyl)-4,4,5,5-tetraMethyl-1,3,2-dioxaborolane
• CAS No.: 1234319-14-2
• Molecular Formula: C13H17BF2O2
• Molecular Weight: 254.085
• Hs Code.: 2934999090
• Mol file: 1234319-14-2.mol

Synonyms:2-(4-(DifluoroMethyl)phenyl)-4,4,5,5-tetraMethyl-1,3,2-dioxaborolane

Chemical Property of 2-(4-(DifluoroMethyl)phenyl)-4,4,5,5-tetraMethyl-1,3,2-dioxaborolane

Chemical Property:

• PSA: 18.46000
• LogP: 2.92340
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

2-(4-(Difluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-(DifluoroMethyl)phenyl)-4,4,5,5-tetraMethyl-1,3,2-dioxaborolane

There total 5 articles about 2-(4-(DifluoroMethyl)phenyl)-4,4,5,5-tetraMethyl-1,3,2-dioxaborolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

→ 2-(4-(difluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1234319-14-2)

Guidance literature:

With dmap; 4,4'-diamino-2,2'-bipyridyl; magnesium chloride; nickel dichloride; zinc; In N,N-dimethyl acetamide; at 60 ℃; for 12h; Molecular sieve;

Reference yield: 39.0%

p-bromo-α,α-difluorotoluene (51776-71-7) + bis(pinacol)diborane (73183-34-3) → 2-(4-(difluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1234319-14-2)

Guidance literature:

With potassium acetate; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; In 1,4-dioxane; at 100 ℃; for 18h;

Reference yield: 18.0%

bromodifluoromethane (1511-62-2) + p-bromophenylboronic acid pinacol ester (68716-49-4) → 2-(4-(difluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1234319-14-2)

Guidance literature:

p-bromophenylboronic acid pinacol ester; With 2,6-dimethylpyridine; tris-(trimethylsilyl)silane; [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate; 4,4'-di-tert-butyl-2,2'-bipyridine; In 1,2-dimethoxyethane; for 0.25h; Inert atmosphere;

bromodifluoromethane; In 1,2-dimethoxyethane; at 30 ℃; for 18h; Sealed tube; Irradiation; Inert atmosphere;

DOI:10.1002/anie.201807629

upstream raw materials:

p-bromo-α,α-difluorotoluene

bis(pinacol)diborane

4-bromo-benzaldehyde

bromodifluoromethane

Downstream raw materials:

N-(5-(4-(difluoromethyl)phenyl)-2-morpholinopyridin-4-yl)-5,7-difluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-amine

(4-(3-(4-(difluoromethyl)phenyl)imidazo[1,2-a]pyrazin-6-yl)phenyl)(4-methylpiperazin-1-yl)methanone

(S)-2-(tertbutoxy)-2-(4-(4-(difluoromethyl)phenyl)-2-methyl-5,6,7,8-tetrahvdrobenzo[4,5]thieno[2,3-b]pyridin-3-yl)acetic acid

(S)-methyl 2-(tert-butoxy)-2-(4-(4-(difluoromethyl)phenyl)-2-methyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-b]pyridin-3-yl)acetate

Refernces

• 1、 Zhang, Xue,Ling, Liang,Luo, Meiming,Zeng, Xiaoming. "Accessing Difluoromethylated and Trifluoromethylated cis-Cycloalkanes and Saturated Heterocycles: Preferential Hydrogen Addition to the Substitution Sites for Dearomatization". supporting information. p. 16785 - 16789. Retrieved 2019/11/11.
• 2、 -. "4-AMINO-6-(4-SUBSTITUTED-PHENYL)-PICOLINATES AND 6-AMINO-2-(4-SUBSTITUTED-PHENYL)-PYRIMIDINE-4-CARBOXYLATES AND THEIR USE AS HERBICIDES". Paragraph 0260; 0261; 0262; 0263; 0264. . Retrieved 2014/09/29.