D-Phenylalanyl Nateglinide

Base Information

• Chemical Name: D-Phenylalanyl Nateglinide
• CAS No.: 944746-48-9
• Molecular Formula: C₂₈H₃₆N₂O₄
• Molecular Weight: 464.605
• Mol file: 944746-48-9.mol

Synonyms:D-Phenylalanyl Nateglinide;N-[(trans-4-Isopropylcyclohexyl)carbonyl]-D-phenylalanyl-D-phenylalanine;N-[[trans-4-(1-Methylethyl)cyclohexyl]carbonyl]-D-phenylalanyl-D-phenylalanine;Nateglinide EP Impurity F

Chemical Property of D-Phenylalanyl Nateglinide

Chemical Property:

• PSA: 102.48000
• LogP: 5.66900

Purity/Quality:

95% ^*data from raw suppliers

D-PhenylalanylNateglinide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: D-Phenylalanyl Nateglinide is an impurity of the oral hypoglycemic agent Nateglinide (N379375) used in forced degradation studies.

Technology Process of D-Phenylalanyl Nateglinide

There total 1 articles about D-Phenylalanyl Nateglinide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

trans-4-isopropylcyclohexane-1-carboxylic acid (7077-05-6) + D-(R)-phenylalanine (673-06-3,25191-15-5,658-69-5,67675-33-6) + chloroformic acid ethyl ester (541-41-3) → N-(ethoxycarbonyl)-(D)-phenylalanine (21488-23-3) + nateglinide (105816-04-4,105816-05-5) + 2-[2-[(trans-4-isopropylcyclohexanecarbonyl)amino]-3-phenylpropionylamino]-3-phenylpropionic acid (944746-48-9)

Guidance literature:

trans-4-isopropylcyclohexane-1-carboxylic acid; chloroformic acid ethyl ester; With triethylamine; In acetone; at -10 - -5 ℃; for 1.25h;

D-(R)-phenylalanine; With 4-methyl-morpholine; triethylamine; In water; acetone; at -10 - -5 ℃;

DOI:10.1080/00304940409356630

upstream raw materials:

trans-4-isopropylcyclohexane-1-carboxylic acid

D-(R)-phenylalanine

chloroformic acid ethyl ester

Refernces