2-(diMethylphosphoryl)aniline

Base Information

• Chemical Name: 2-(diMethylphosphoryl)aniline
• CAS No.: 1197953-47-1
• Molecular Formula: C8H12NO3P
• Molecular Weight: 169.163
• Hs Code.: 2923900090
• Mol file: 1197953-47-1.mol

Synonyms:2-(diMethylphosphoryl)aniline;2-(diMethylphosphoryl)benzenaMine;(2-AMinophenyl)diMethylphosphine oxide;Benzenamine, 2-(dimethylphosphinyl)-;2-(Dimethylphosphinyl)benzenamine;2-(Dimethylphosphinyl)benzeneamine;1197953-47-1

Chemical Property of 2-(diMethylphosphoryl)aniline

Chemical Property:

• Boiling Point: 367.5±34.0 °C(Predicted)
• PKA: 1.10±0.10(Predicted)
• PSA: 52.90000
• Density: 1.11±0.1 g/cm3(Predicted)
• LogP: 2.09800
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

99.0%, High purity. ^*data from raw suppliers

(2-Aminophenyl)dimethylphosphineOxide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(diMethylphosphoryl)aniline

There total 4 articles about 2-(diMethylphosphoryl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2-iodophenylamine (615-43-0) + dimethyl phosphine oxide (7211-39-4) → (2-aminophenyl)dimethyl phosphorus oxide (1197953-47-1)

Guidance literature:

With potassium phosphate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In N,N-dimethyl-formamide; at 120 ℃; Inert atmosphere;

Reference yield: 79.6%

dimethylphosphane (676-59-5) + 2-iodophenylamine (615-43-0) → (2-aminophenyl)dimethyl phosphorus oxide (1197953-47-1)

Guidance literature:

With potassium phosphate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In water; N,N-dimethyl-formamide; at 110 - 125 ℃; for 3h; Inert atmosphere;

Reference yield: 75.0%

dimethyl (2-aminophenyl)phosphonate (15286-21-2) + methylmagnesium chloride (676-58-4) → (2-aminophenyl)dimethyl phosphorus oxide (1197953-47-1)

Guidance literature:

dimethyl (2-aminophenyl)phosphonate; methylmagnesium chloride; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

In tetrahydrofuran; water;

upstream raw materials:

2-iodophenylamine

dimethyl phosphine oxide

dimethylphosphane

dimethyl (2-aminophenyl)phosphonate

Refernces

• 1、 -. "Preparation method of intermediate (2-aminophenyl)dimethyl phosphine oxide of Brigatinib". Paragraph 0100; 0106-0112. . Retrieved 2020/02/14.
• 2、 -. "Polymorphism of novel spiroarylphosphine oxide". Paragraph 0114; 0118-0120. . Retrieved 2019/11/20.