PHENYLSUCCINIC ACID

Base Information

• Chemical Name: PHENYLSUCCINIC ACID
• CAS No.: 10424-29-0
• Molecular Formula: C₁₀H₁₀O₄
• Molecular Weight: 194.187
• Mol file: 10424-29-0.mol

Synonyms:phenylsuccinicacid96+%;Phenyl Succinic Aci

Chemical Property of PHENYLSUCCINIC ACID

Chemical Property:

• Vapor Pressure: 0.000306mmHg at 25°C
• Melting Point: 166-169℃
• Refractive Index: 1.5430 (estimate)
• Boiling Point: 307.8°C at 760 mmHg
• Flash Point: 154.2°C
• PSA: 74.60000
• Density: 1.2534 (rough estimate)
• LogP: 1.32950

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Hazard Codes: Xi:Irritant
• Statements: R36/37/38:
• Safety Statements: S26:; S37/39:

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of PHENYLSUCCINIC ACID

There total 96 articles about PHENYLSUCCINIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

C20H20O6 → 2-phenylsuccinic acid (635-51-8,10424-29-0)

Guidance literature:

With hydrogenchloride; In water; for 24h; Reflux;

DOI:10.1002/cctc.202000684

Reference yield: 90.0%

carbon dioxide (124-38-9,18923-20-1) + phenylacetylene (536-74-3) → 2-phenylmaleic anhydride (36122-35-7) + 2-phenylsuccinic acid (635-51-8,10424-29-0)

Guidance literature:

With tetrabutylammomium bromide; In water; N,N-dimethyl-formamide; at 20 ℃; under 22502.3 Torr; Electrochemical reaction; Ni cathode; Al anode;

DOI:10.1016/j.tet.2008.04.053

Reference yield: 87.0%

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + carbon dioxide (124-38-9,18923-20-1) → 2-phenylsuccinic acid (635-51-8,10424-29-0) + 3-Phenylpropionic acid (501-52-0)

Guidance literature:

With 1,2,2,6,6-pentamethylpiperidine; [1,1';4',1'']terphenyl; water; In hexane; N,N-dimethyl-formamide; at 35 - 38 ℃; for 0.0833333h; under 760.051 Torr; Catalytic behavior; Schlenk technique; UV-irradiation; Flow reactor;

DOI:10.1021/jacs.7b05942

upstream raw materials:

5-phenyl-cyclohexane-1,3-dione

(+-)-phenylsuccinonitrile

3-cyano-3-phenyl propionic acid

3-cyano-3-phenylpropanoic acid ethyl ester

Downstream raw materials:

phenyl-succinic acid bis-(1H,1H,7H-dodecafluoro-heptyl ester)

1-(2-hydroxy-ethyl)-3-phenyl-pyrrolidine-2,5-dione

1-(2-diethylamino-ethyl)-3-phenyl-pyrrolidine-2,5-dione

4-Nitrophenylsuccinic acid

Refernces

• 1、 Ren, Yuan-Yuan,Mao, Hong-Xiang,Hu, Meng-Yang,Zhu, Shou-Fei,Zhou, Qi-Lin. "Cu/PCy3-Catalyzed Formal Carbene Insertion into Electron-Deficient C?H Bonds". . p. 4267 - 4271. Retrieved 2020.
• 2、 Rokach,J.,Elad,D.. "-". . p. 4210 - 4215. Retrieved 1966.
• 3、 Gan, Zong-Jie,Wang, Yu-Hua,Xu, Yun-Gen,Guo, Ting,Wang, Jun,Song, Qiao,Xu, Xue-Jun,Hu, Shi-Yuan,Wang, Yu-Jun,Wang, De-Chuan,Sun, De-Zhu,Zhang, Di,Xi, Tao,Li, Hao-Dong,Zhang, Hai-Bo,Hang, Tai-Jun,Lu, Hong-Guo,Liu, Jing-Gen. "Discovery, stereospecific characterization and peripheral modification of 1-(pyrrolidin-1-ylmethyl)-2-[(6-chloro-3-oxo-indan)-formyl]-1,2,3,4-tetrahydroisoquinolines as novel selective κ opioid receptor agonists". . p. 5656 - 5673. Retrieved 2015.
• 4、 Alkayal, Anas,Buckley, Benjamin R.,Malkov, Andrei V.,Montanaro, Stephanie,Tabas, Volodymyr,Wright, Iain A.. "Harnessing Applied Potential: Selective β-Hydrocarboxylation of Substituted Olefins". supporting information. . Retrieved 2020/02/13.