ETHYL (R)-2-AMINO-2-METHYLBUTYRATE

Base Information

• Chemical Name: ETHYL (R)-2-AMINO-2-METHYLBUTYRATE
• CAS No.: 40916-97-0
• Molecular Formula: C7H15NO2
• Molecular Weight: 145.202
• Mol file: 40916-97-0.mol

Synonyms:ETHYL (R)-2-AMINO-2-METHYLBUTYRATE

Chemical Property of ETHYL (R)-2-AMINO-2-METHYLBUTYRATE

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL (R)-2-AMINO-2-METHYLBUTYRATE

There total 3 articles about ETHYL (R)-2-AMINO-2-METHYLBUTYRATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

C11H23NO3S → (R)-2-Amino-2-methyl-butyric acid ethyl ester (40916-97-0)

Guidance literature:

With hydrogenchloride; In methanol; at 20 ℃;

Reference yield:

Ethyl 2-oxobutanoate (15933-07-0) → (R)-2-Amino-2-methyl-butyric acid ethyl ester (40916-97-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: titanium(IV) tetraethanolate / tetrahydrofuran / 6 h / 65 °C / Inert atmosphere

2.1: dimethyl zinc(II) / tetrahydrofuran / 0.17 h / Inert atmosphere

2.2: 2 h / -78 °C

3.1: hydrogenchloride / methanol / 20 °C

With hydrogenchloride; titanium(IV) tetraethanolate; dimethyl zinc(II); In tetrahydrofuran; methanol;

Reference yield:

C10H19NO3S → (R)-2-Amino-2-methyl-butyric acid ethyl ester (40916-97-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dimethyl zinc(II) / tetrahydrofuran / 0.17 h / Inert atmosphere

1.2: 2 h / -78 °C

2.1: hydrogenchloride / methanol / 20 °C

With hydrogenchloride; dimethyl zinc(II); In tetrahydrofuran; methanol;

upstream raw materials:

Ethyl 2-oxobutanoate

Downstream raw materials:

(2R)-2-amino-2-methylbutanoic acid

Refernces