4-hydroxy-3-sulfanylbenzoic acid

Base Information

• Chemical Name: 4-hydroxy-3-sulfanylbenzoic acid
• CAS No.: 59780-96-0
• Molecular Formula: C₇H₆O₃S
• Molecular Weight: 170.189
• Mol file: 59780-96-0.mol

Synonyms:

Chemical Property of 4-hydroxy-3-sulfanylbenzoic acid

Chemical Property:

• Vapor Pressure: 4.52E-06mmHg at 25°C
• Boiling Point: 368.2°Cat760mmHg
• Flash Point: 176.5°C
• Density: 1.506g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-hydroxy-3-sulfanylbenzoic acid

There total 4 articles about 4-hydroxy-3-sulfanylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(chlorosulfonyl)-4-hydroxybenzoic acid (77719-02-9) + zinc (7440-66-6) → 3-mercapto-4-hydroxybenzoic acid (59780-96-0)

Guidance literature:

In hydrogenchloride; acetic acid;

Reference yield:

3-(chlorosulfonyl)-4-hydroxybenzoic acid (77719-02-9) → 3-mercapto-4-hydroxybenzoic acid (59780-96-0)

Guidance literature:

With triphenylphosphine; In tetrahydrofuran; toluene; for 15h; Inert atmosphere;

DOI:10.1039/c5ob01805f

Reference yield:

4-hydroxy-benzoic acid (99-96-7) → 3-mercapto-4-hydroxybenzoic acid (59780-96-0)

Guidance literature:

Multi-step reaction with 2 steps

1: chlorosulfonic acid / 15 h / 20 °C / Inert atmosphere

2: triphenylphosphine / tetrahydrofuran; toluene / 15 h / Inert atmosphere

With chlorosulfonic acid; triphenylphosphine; In tetrahydrofuran; toluene;

DOI:10.1039/c5ob01805f

upstream raw materials:

3-(chlorosulfonyl)-4-hydroxybenzoic acid

zinc

4-hydroxy-benzoic acid

Refernces

• 1、 -. "HYPOTENSIVE BENZOXATHIOLE PYRROLIDINES". . . Retrieved 2008/06/13.