Codeine β-D-Glucuronide Triacetate Methyl Ester

Base Information

• Chemical Name: Codeine β-D-Glucuronide Triacetate Methyl Ester
• CAS No.: 20736-10-1
• Molecular Formula: C31H37NO12
• Molecular Weight: 615.62498
• Mol file: 20736-10-1.mol

Synonyms:Codeine β-D-Glucuronide Triacetate Methyl Ester;7,8-Didehydro-4,5α-epoxy-3-Methoxy-17-MethylMorphinan-6α-yl β-D-Glucopyranosiduronic Acid 2,3,4-Τriacetate Μethyl Εster;7,8-Didehydro-4,5α-epoxy-6α-(β-D-glucopyranuronosyloxy)-3-Methoxy-17-Methyl-Morphinan;Codeine beta-D-glucuronide triacetate methyl ester;O3-Methylmorphine 6-(tri-O-acetyl-6-methyl-beta-D-glucopyranuronoside)

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of Codeine β-D-Glucuronide Triacetate Methyl Ester

Chemical Property:

• Boiling Point: 664.5±55.0 °C(Predicted)
• PKA: 8.08±0.40(Predicted)
• PSA: 145.36000
• Density: 1.39±0.1 g/cm3(Predicted)
• LogP: 1.15630

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A protected metabolite of Codeine (C634075).

Technology Process of Codeine β-D-Glucuronide Triacetate Methyl Ester

There total 3 articles about Codeine β-D-Glucuronide Triacetate Methyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,3,4-tri-O-acetyl-1-bromo-1-deoxy-β-D-glucopyranuronic acid methy ester (6919-98-8) + codeine (76-57-3) → methyl[codein-6-yl-2,3,4-tri-O-acetyl-β-D-glucopyranosid]uronate (20736-10-1)

Guidance literature:

With silver carbonate; In benzene;

DOI:10.1023/A:1016059618633

Reference yield:

codeine (76-57-3) + 1-bromo-2,3,4-tri-O-acetyl-α-D-glucuronic acid methyl ester (21085-72-3) → methyl[codein-6-yl-2,3,4-tri-O-acetyl-β-D-glucopyranosid]uronate (20736-10-1)

Guidance literature:

With Celite; silver carbonate; In toluene; for 3h; Heating;

DOI:10.1016/0040-4039(95)00649-W

Reference yield:

codeine (76-57-3) + 3-O-acetylmorphine (5140-28-3) → methyl[codein-6-yl-2,3,4-tri-O-acetyl-β-D-glucopyranosid]uronate (20736-10-1) + C31H37NO12

Guidance literature:

With 4 A molecular sieve; zinc dibromide; In dichloromethane; Further Variations:; reagent amounts; Product distribution; Heating;

DOI:10.1016/S0040-4020(00)01080-2

upstream raw materials:

codeine

1-bromo-2,3,4-tri-O-acetyl-α-D-glucuronic acid methyl ester

3-O-acetylmorphine

2,3,4-tri-O-acetyl-1-bromo-1-deoxy-β-D-glucopyranuronic acid methy ester

Downstream raw materials:

Codeine-6-glucuronide

Refernces

• 1、 Lacy, Christopher. "A synthesis of morphine-6-glucuronide". . p. 3949 - 3950. Retrieved 1995.