1-(4-(benzyloxy)-6-methoxybenzofuran-2-yl)-2-bromoethanone

Base Information

• Chemical Name: 1-(4-(benzyloxy)-6-methoxybenzofuran-2-yl)-2-bromoethanone
• CAS No.: 1476847-52-5
• Molecular Formula: C18H15BrO4
• Molecular Weight: 375.219
• Mol file: 1476847-52-5.mol

Synonyms:1-(4-(benzyloxy)-6-methoxybenzofuran-2-yl)-2-bromoethanone;1-(4-(benzyloxy)-6-methoxybenzofuran-2-yl)-2-bromoethan-1-one

Chemical Property of 1-(4-(benzyloxy)-6-methoxybenzofuran-2-yl)-2-bromoethanone

Chemical Property:

• Boiling Point: 488.8±40.0 °C(Predicted)
• PSA: 48.67000
• Density: 1.444±0.06 g/cm3(Predicted)
• LogP: 4.59800

Purity/Quality:

98.5% ^*data from raw suppliers

1-(4-(Benzyloxy)-6-methoxybenzofuran-2-yl)-2-bromoethanone 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(4-(benzyloxy)-6-methoxybenzofuran-2-yl)-2-bromoethanone

There total 16 articles about 1-(4-(benzyloxy)-6-methoxybenzofuran-2-yl)-2-bromoethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

1-[4-(benzyloxy)-6-methoxy-1-benzofuran-2-yl]ethan-1-one (1476847-51-4) → 1-(4-(benzyloxy)-6-methoxybenzofuran-2-yl)-2-bromoethanone (1476847-52-5)

Guidance literature:

1-[4-(benzyloxy)-6-methoxy-1-benzofuran-2-yl]ethan-1-one; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.75h; Inert atmosphere;

With chloro-trimethyl-silane; In tetrahydrofuran; at -78 ℃; for 0.333333h;

With N-Bromosuccinimide; sodium hydrogencarbonate; In tetrahydrofuran; at 0 ℃; for 2h;

Reference yield:

C21H24O4Si → 1-(4-(benzyloxy)-6-methoxybenzofuran-2-yl)-2-bromoethanone (1476847-52-5)

Guidance literature:

With N-Bromosuccinimide; sodium hydrogencarbonate; In tetrahydrofuran; at -20 - 0 ℃; for 2.25h;

Reference yield:

toluene-ethyl acetate → 1-(4-(benzyloxy)-6-methoxybenzofuran-2-yl)-2-bromoethanone (1476847-52-5)

Guidance literature:

With N-Bromosuccinimide; sodium hydrogencarbonate; In tetrahydrofuran; ethyl acetate;

upstream raw materials:

benzyl bromide

5-(benzyloxy)-7-methoxy-2,2-dimethyl-4H-benzo[d][1,3 ]dioxin-4-one

5-hydroxy-7-methoxy-2,2-dimethyl-benzo[1,3]dioxin-4-one

2-(benzyloxy)-6-hydroxy-4-methoxybenzaldehyde

Downstream raw materials:

2-(4-(benzyloxy)-6-methoxybenzofuran-2-yl)-6-methylimidazo[1,2-b]pyridazine

(S)-6-(4-(benzyloxy)-6-methoxybenzofuran-2-yl)-2-(1-fluoroethyl)imidazo[2,1-b][1,3,4]thiadiazole

2-Methoxy-6-(6-methoxy-4-((5-phenyl-1,3,4-thiadiazol-2-yl)methoxy)benzofuran-2-yl)imidazo[2,1-b][1,3,4]thiadiazole

2-Methoxy-6-(6-methoxy-4-((1-phenyl-1H-1,2,3-triazol-4-yl)methoxy)benzofuran-2-yl)imidazo[2,1-b][1,3,4]thiadiazole

Refernces

• 1、 Miller, Michael M.,Banville, Jacques,Friends, Todd J.,Gagnon, Mark,Hangeland, Jon J.,Lavallée, Jean-Fran?ois,Martel, Alain,O'Grady, Harold,Rémillard, Roger,Ruediger, Edward,Tremblay, Fran?ois,Posy, Shana L.,Allegretto, Nick J.,Guarino, Victor R.,Harden, David G.,Harper, Timothy W.,Hartl, Karen,Josephs, Jonathan,Malmstrom, Sarah,Watson, Carol,Yang, Yanou,Zhang, Ge,Wong, Pancras,Yang, Jing,Bouvier, Michel,Seiffert, Dietmar A.,Wexler, Ruth R.,Lawrence, R. Michael,Priestley, E. Scott,Marinier, Anne. "Discovery of Potent Protease-Activated Receptor 4 Antagonists with in Vivo Antithrombotic Efficacy". . p. 7400 - 7416. Retrieved 2019/08/26.
• 2、 -. "Benzofuran derivatives, preparation method thereof and application of the derivatives in medicine". Paragraph 0487; 0489; 0490-0492. . Retrieved 2019/10/01.