Technology Process of (R)-methyl 2-(isopropylamino)butanoate
There total 3 articles about (R)-methyl 2-(isopropylamino)butanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(R)-2-aminobutyric acid; trimethyl orthoformate;
With
thionyl chloride;
In
methanol;
at 50 - 60 ℃;
for 3.5h;
Heating / reflux;
acetone;
With
sodium tris(acetoxy)borohydride;
In
toluene;
at 20 - 60 ℃;
for 16h;
With
hydrogenchloride; ammonia; water;
more than 3 stages;
- Guidance literature:
-
(R)-2-aminobutyric acid; trimethyl orthoformate;
With
thionyl chloride;
In
methanol;
at 50 - 60 ℃;
for 3.5h;
Heating / reflux;
acetone;
With
sodium tris(acetoxy)borohydride;
In
toluene;
at 20 - 60 ℃;
for 16h;
With
ammonia; water;
In
toluene;
at 50 ℃;
- Guidance literature:
-
(R)-2-aminobutyric acid methyl ester hydrochloride; acetone;
With
acetic acid;
In
tetrahydrofuran;
at 20 - 30 ℃;
for 1h;
Inert atmosphere;
With
sodium tetrahydroborate;
In
tetrahydrofuran;
at 10 - 30 ℃;
for 2h;
Inert atmosphere;
With
hydrogenchloride;
In
tetrahydrofuran; ethyl acetate; toluene;
at 0 - 10 ℃;
for 1h;
DOI:10.1016/j.tet.2018.08.020
