CYTIDYLYL-(3'->5')-GUANOSINE

Base Information

• Chemical Name: CYTIDYLYL-(3'->5')-GUANOSINE
• CAS No.: 2382-65-2
• Molecular Formula: C19H25 N8 O12 P
• Molecular Weight: 588.428
• Mol file: 2382-65-2.mol

Synonyms:(3'-5')CpG;4: PN: US20050272923 PAGE: 4 claimed sequence; Cytidine, guanylyl-(5'®3')-;Cytidylyl-(3',5')-guanosine; Cytidylylguanosine; Guanosine cytidine3',5'-monophosphate

Chemical Property of CYTIDYLYL-(3'->5')-GUANOSINE

Chemical Property:

• Boiling Point: 1057.6°Cat760mmHg
• Flash Point: 593.4°C
• PSA: 317.43000
• Density: 2.31g/cm³
• LogP: -3.40230

Purity/Quality:

99%, ^*data from raw suppliers

CYTIDYLYL-(3'-,5')-GUANOSINE 98.00% ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of CYTIDYLYL-(3'->5')-GUANOSINE

There total 5 articles about CYTIDYLYL-(3'->5')-GUANOSINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ [5']guanylic acid cytidin-3'-yl ester (2382-65-2)

Guidance literature:

With bismuth Hydroxide; water; at 100 ℃; Loesung vom pH 4;

Reference yield:

Phosphoric acid (2R,3S,4R,5R)-5-(2-amino-6-oxo-1,6-dihydro-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl ester (2R,3R,4R,5R)-2-(4-amino-2-oxo-2H-pyrimidin-1-yl)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-3-yl ester (22886-38-0) → [5']guanylic acid cytidin-3'-yl ester (2382-65-2)

Guidance literature:

With 1H-imidazole; sodium chloride; magnesium chloride; In water; at 200 ℃; pH=8.00; Further Variations:; Temperatures; Kinetics;

DOI:10.1246/bcsj.76.153

Reference yield:

C79H84ClN8O24P → [5']guanylic acid cytidin-3'-yl ester (2382-65-2)

Guidance literature:

With ammonium hydroxide; 4-nitrobenzaldoxime; N,N,N',N'-tetramethylguanidine; Yield given. Multistep reaction; 1.) dioxane/water, r.t., 24 h, 2.) 50 deg C, 2 d;

DOI:10.1016/S0040-4020(01)82001-9

upstream raw materials:

Phosphoric acid (2R,3S,4R,5R)-5-(2-amino-6-oxo-1,6-dihydro-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl ester (2R,3R,4R,5R)-2-(4-amino-2-oxo-2H-pyrimidin-1-yl)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-3-yl ester

Downstream raw materials:

cytidine 2',3'-cyclic monophosphate

G

cytidine 3'-monophosphate

cytidine-2'-monophosphate

Refernces

• 1、 Foeldesi, Andras,Nilson, Frans Peder R.,Glemarec, Corine,Gioeli, Carlo,Chattopadhyaya, Jyoti. "Synthesis of 1'%,2',3',4'%,5',5"-(2)H6-β-D-ribonucleosides and 1'%,2',2",3',4'%,5',5"-(2)H7-β-D-2'-deoxyribonucleosides for Selective Suppression of Proton Resonances in Partially-deuterated Oligo-DNA, Oligo-RNA and in 2,5A core ((1)H-NMR window)". . p. 9033 - 9072. Retrieved 2007/10/02.