Olanzapine Pamoate Hydrate

Base Information

• Chemical Name: Olanzapine Pamoate Hydrate
• CAS No.: 221373-18-8
• Molecular Formula: C40H38N4O7S
• Molecular Weight: 718.81732
• Mol file: 221373-18-8.mol

Synonyms:Olanzapine Pamoate Hydrate;2-Methyl-4-(4-Methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine 4,4'-Methylenebis[3-hydroxy-2-naphthalenecarboxylate] Monohydrate;4,4'-Methylenebis[3-hydroxy-2-naphthalenecarboxylic Acid coMpound with 2-Methyl-4-(4-Methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine Hydrate

Chemical Property of Olanzapine Pamoate Hydrate

Chemical Property:

• PSA: 183.40000
• LogP: 7.21570

Purity/Quality:

98%,99%, ^*data from raw suppliers

OlanzapinePamoateHydrate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: A new Olanzapine pamoate formulation of a second-generation antipsychotic

Technology Process of Olanzapine Pamoate Hydrate

There total 5 articles about Olanzapine Pamoate Hydrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

zyprexa (132539-06-1) + Pamoic acid (130-85-8) → olanzapine pamoate monohydrate (221373-18-8)

Guidance literature:

Pamoic acid; With ammonium hydroxide; In water;

zyprexa; With hydrogenchloride; water; at 25 - 30 ℃; Reagent/catalyst;

Reference yield:

relprevv → 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2.3-b][1,5]benzodiazepine pamoate dihydrate (221373-18-8)

Guidance literature:

relprevv; In dimethyl sulfoxide; acetonitrile;

With water; In dimethyl sulfoxide; acetonitrile; for 1h; Product distribution / selectivity;

Reference yield:

olanzapine pamoate monohydrate (221373-18-8) → 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2.3-b][1,5]benzodiazepine pamoate dihydrate (221373-18-8)

Guidance literature:

With water; In acetonitrile; for 144h; Product distribution / selectivity;

upstream raw materials:

zyprexa

Pamoic acid

Refernces

• 1、 -. "OLANZAPINE PAMOATE DIHYDRATE". Page/Page column 6. . Retrieved 2008/06/13.