ETHYL 4-(2,6-DIFLUOROPHENYL)-4-OXOBUTYRATE

Base Information

• Chemical Name: ETHYL 4-(2,6-DIFLUOROPHENYL)-4-OXOBUTYRATE
• CAS No.: 4930-04-5
• Molecular Formula: C12H12F2O3
• Molecular Weight: 224.216
• Mol file: 4930-04-5.mol

Synonyms:ETHYL 4-(2,6-DIFLUOROPHENYL)-4-OXOBUTYRATE

Chemical Property of ETHYL 4-(2,6-DIFLUOROPHENYL)-4-OXOBUTYRATE

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 4-(2,6-DIFLUOROPHENYL)-4-OXOBUTYRATE

There total 9 articles about ETHYL 4-(2,6-DIFLUOROPHENYL)-4-OXOBUTYRATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + 1,3-Phenylene diisocyanate (123-61-5) → dimethyl N,N'-(1,3-phenylene)dicarbamate (4930-04-5)

Guidance literature:

for 4h; Heating;

Reference yield: 85.0%

methanol (67-56-1) + m-phenylenediamine (108-45-2,64554-26-3,76583-20-5) → dimethyl N,N'-(1,3-phenylene)dicarbamate (4930-04-5)

Guidance literature:

With iron(II,III) oxide; manganese (IV) dioxide; oxygen; at 100 ℃; for 20h; under 3750.38 Torr; Autoclave;

Reference yield: 79.0%

methanol (67-56-1) + meta-dinitrobenzene (99-65-0) + formyl radical (2597-44-6) → dimethyl N,N'-(1,3-phenylene)dicarbamate (4930-04-5)

Guidance literature:

With 1,10-Phenanthroline; [trihexyl(tetradecyl)phosphonium hexafluorophosphate]; palladium dichloride; at 135 ℃; for 24h; under 10343.2 Torr;

DOI:10.1021/ol802096x

upstream raw materials:

methanol

1,3-Phenylene diisocyanate

meta-dinitrobenzene

carbon monoxide

Downstream raw materials:

N,N'-(4-nitro-m-phenylene)-bis-carbamic acid dimethyl ester

1,3-Phenylene diisocyanate

Refernces

• 1、 -. "ONE-POT PRODUCTION OF CARBAMATES USING SOLID CATALYSTS". Page/Page column 5. . Retrieved 2012/02/04.
• 2、 Yang, Qian,Robertson, Al,Alper, Howard. "Efficient palladium/1,10-phenanthroline-catalyzed reductive carbonylation of mono- and dinitroarenes to urethanes in phosphonium salt ionic liquids". experimental part. p. 5079 - 5082. Retrieved 2009/05/07.