Loratadine EP IMpurity F

Base Information

• Chemical Name: Loratadine EP IMpurity F
• CAS No.: 125743-80-8
• Molecular Formula: C22H23ClN2O2
• Molecular Weight: 382.88322
• UNII: VLO9J5175E
• Nikkaji Number: J2.862.572C
• Wikidata: Q27291884
• Mol file: 125743-80-8.mol

Synonyms:Loratadine EP IMpurity F;1-Piperidinecarboxylic acid, 4-( 8-chloro-11-fluoro-6,11-dihydro -5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-, ethyl ester;Ethyl 4-[(11RS)-8-chloro-11-fluoro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl]piperidine-1-carboxylate

Chemical Property of Loratadine EP IMpurity F

Chemical Property:

• Melting Point: 149-153 °C
• Boiling Point: 490.3±45.0 °C(Predicted)
• PKA: 3.65±0.40(Predicted)
• PSA: 42.43000
• Density: 1.29±0.1 g/cm3(Predicted)
• LogP: 4.85310
• XLogP3: 4.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 402.1510339
• Heavy Atom Count: 28
• Complexity: 557

Purity/Quality:

99%+, ^*data from raw suppliers

Loratadine impurity F ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)N1CCC(CC1)C2(C3=C(CCC4=C2N=CC=C4)C=C(C=C3)Cl)F
• Uses: Loratadine Impurity F (Loratadine EP Impurity F; Loratadine USP Related Compound G Impurity) is a fluorinated analog of Loratadine (L469575), which is a nonsedating-type histamine H1-receptor.

Technology Process of Loratadine EP IMpurity F

There total 1 articles about Loratadine EP IMpurity F which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ Fluoroloratadine (125743-80-8)

Guidance literature:

Refernces