Diacylglycerol kinase inhibitor II

Base Information

• Chemical Name: Diacylglycerol kinase inhibitor II
• CAS No.: 120166-69-0
• Molecular Formula: C28H25F2N3OS
• Molecular Weight: 489.58
• European Community (EC) Number: 634-242-9
• DSSTox Substance ID: DTXSID70152707
• Nikkaji Number: J387.641A
• Wikidata: Q27077044
• ChEMBL ID: CHEMBL261131
• Mol file: 120166-69-0.mol

Synonyms:3-(2-(4-(bis(4-fluorophenyl)methylene)-1-piperdinyl)ethyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone;R 59 949;R 59949;R-59949;R59949

Chemical Property of Diacylglycerol kinase inhibitor II

Chemical Property:

• Vapor Pressure: 3.94E-16mmHg at 25°C
• Refractive Index: 1.688
• Boiling Point: 637.1 °C at 760 mmHg
• PKA: 11.24±0.20(Predicted)
• Flash Point: 339.1 °C
• PSA: 73.12000
• Density: 1.36 g/cm³
• LogP: 5.87310
• Storage Temp.: −20°C
• Solubility.: 0.1 M HCl: slightly soluble
• XLogP3: 5.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 489.16863993
• Heavy Atom Count: 35
• Complexity: 770

Purity/Quality:

98%,99%, ^*data from raw suppliers

Diacylglycerol Kinase Inhibitor II solid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1CN(CCC1=C(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F)CCN4C(=O)C5=CC=CC=C5NC4=S
• Description: R-59-949 is an inhibitor of diacylglycerol kinase α (DGK-α) with an IC50 value of 300 nM in isolated platelet plasma membranes using exogenous diacylglycerol as a substrate. DGK-α inhibition with R-59-949 increases diacylglycerol-dependent PKC activity, serotonin secretion, and aggregation of thrombin-stimulated platelets. R-59-949 inhibits DGK-α activity induced by platelet-derived growth factor (PDGF) in intact vascular smooth muscle cells (VSMCs). It inhibits high K+- and glucose-induced insulin secretion in MIN6 pancreatic β-cells in a dose-dependent manner. In vivo, administration of R-59-949 prevents retinal neovascularization in a mouse model of oxygen-induced retinopathy.
• Uses: Diacylglycerol Kinase Inhibitor II has been used to determine tumor-induced inhibition with genetically modified cytotoxic T cells expressing chimeric antigen receptors (CAR). It has also been used to induce pAkt and PKR-like extracellular signal-regulated kinase (pErk) signals in T-cell acute lymphoblastic leukemia (T-ALL) cells.