METHOHEXITAL

Base Information

• Chemical Name: METHOHEXITAL
• CAS No.: 18652-93-2
• Molecular Formula: C₁₄H₁₈N₂O₃
• Molecular Weight: 262.309
• Mol file: 18652-93-2.mol

Synonyms:Brevimytal natrium;Brietal sodium;Brietal-sodium;D008723;Jones brand of methohexital sodium;Lilly brand of methohexital sodium

Chemical Property of METHOHEXITAL

Chemical Property:

• PSA: 66.48000
• Density: 1.113g/cm³
• LogP: 1.57330

Purity/Quality:

98%Min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Anesthetic (intravenous). Methohexital is used as a general anesthetic in electroconvulsive therapy.

Technology Process of METHOHEXITAL

There total 16 articles about METHOHEXITAL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ methohexital (151-83-7,115621-28-8,115653-70-8,18652-93-2)

Guidance literature:

With dimethyl sulfate;

Reference yield:

→ methohexital (151-83-7,115621-28-8,115653-70-8,18652-93-2)

Guidance literature:

/BRN= 239724/;

Reference yield:

Allyl acetate (591-87-7) + 1-methyl-5-(1'-methylpent-2'-ynyl)barbituric acid (99841-46-0) → (1'R,5R)-methohexital (18652-93-2) + (1'S,5R)-methohexital (18652-93-2) + (1'R,5S)-methohexital (18652-93-2) + (1'S,5S)-methohexital (18652-93-2) + 3,5-diallyl-1-methyl-5-(1'-methylpent-2'-ynyl)barbituric acid

Guidance literature:

With triethylamine; (R)-Ph₂P-o-C₆H₄-CH=N-CH(CH₂OH)-Ph; palladium(II) acetylacetonate; In dichloromethane; toluene; at 38 ℃; for 72h; Product distribution; further chiral phosphane imine ligands;

DOI:10.1002/(sici)1099-0682(199901)1999:1<51::aid-ejic51>3.0.co;2-y

upstream raw materials:

methohexital

Allyl acetate

1-methyl-5-(1'-methylpent-2'-ynyl)barbituric acid

Refernces

• 1、 Brunner, Henri,Ittner, Karl-Peter,Lunz, Dirk,Schmatloch, Stefan,Schmidt, Thomas,Zabel, Manfred. "Highly enriched mixtures of methohexital stereoisomers by palladium-catalyzed allylation and their anaesthetic activity". . p. 855 - 862. Retrieved 2007/10/03.