2-(4-Bromophenyl)-2-fluoroacetic acid

Base Information

• Chemical Name: 2-(4-Bromophenyl)-2-fluoroacetic acid
• CAS No.: 109050-30-8
• Molecular Formula: C8H6BrFO2
• Molecular Weight: 233.037
• Mol file: 109050-30-8.mol

Synonyms:2-(4-Bromophenyl)-2-fluoroacetic acid

Chemical Property of 2-(4-Bromophenyl)-2-fluoroacetic acid

Chemical Property:

• PSA: 37.30000
• LogP: 2.54430

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-Bromophenyl)-2-fluoroacetic acid

There total 2 articles about 2-(4-Bromophenyl)-2-fluoroacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C20H35BrO2Si2 → (4-bromophenyl)(fluoro)acetic acid (109050-30-8)

Guidance literature:

With Selectfluor; In acetonitrile; at 20 ℃; for 0.25h; Inert atmosphere;

DOI:10.1021/ol4009377

Reference yield:

ethyl 2-(4-bromophenyl)-2-fluoroacetate (109064-24-6) → (4-bromophenyl)(fluoro)acetic acid (109050-30-8)

Guidance literature:

With water; potassium carbonate; In methanol; at 20 ℃; for 5h;

DOI:10.1039/c8sc05096a

Reference yield: 87.4%

(4-bromophenyl)(fluoro)acetic acid (109050-30-8) → (R)-2-(4-bromophenyl)-2-hydroxyacetic acid (6940-50-7,7021-04-7,123484-90-2,32189-34-7) + C8H6BrFO2

Guidance literature:

With fluoroacetate dehalogenase RPA₁₁₆₃-W₁₈₅T; for 1h; enantioselective reaction; Catalytic behavior; Kinetics; Enzymatic reaction;

DOI:10.1021/acscatal.9b04804

upstream raw materials:

ethyl 2-(4-bromophenyl)-2-fluoroacetate

Downstream raw materials:

p-bromo-α,α-difluorotoluene

(R)-2-(4-bromophenyl)-2-hydroxyacetic acid

methyl (±)-2-(4-bromophenyl)-2-fluoroacetate

Refernces

• 1、 Verhoog, Stefan,Pfeifer, Lukas,Khotavivattana, Tanatorn,Calderwood, Samuel,Collier, Thomas Lee,Wheelhouse, Katherine,Tredwell, Matthew,Gouverneur, Véronique. "Silver-Mediated 18F-Labeling of Aryl-CF3 and Aryl-CHF2 with 18F-Fluoride". supporting information. p. 25 - 28. Retrieved 2015/12/26.