2-(3,5-dimethylbenzoyl)aniline

Base Information

• Chemical Name: 2-(3,5-dimethylbenzoyl)aniline
• CAS No.: 83465-82-1
• Molecular Formula: C15H15NO
• Molecular Weight: 225.29
• Mol file: 83465-82-1.mol

Synonyms:2-(3,5-dimethylbenzoyl)aniline;(2-Aminophenyl)(3,5-dimethylphenyl)methanone

Chemical Property of 2-(3,5-dimethylbenzoyl)aniline

Chemical Property:

• PSA: 43.09000
• LogP: 3.69780
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

(2-Aminophenyl)(3,5-dimethylphenyl)methanone 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(3,5-dimethylbenzoyl)aniline

There total 7 articles about 2-(3,5-dimethylbenzoyl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

C15H15NO4S → (2-aminophenyl)(3,5-dimethylphenyl)methanone (83465-82-1)

Guidance literature:

With dipotassium hydrogenphosphate; [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate; triphenylphosphine; In 1,4-dioxane; at 20 ℃; for 8h; Inert atmosphere; Irradiation;

Reference yield: 8.0%

2-methyl-4-oxo-3,1-benzoxazine (525-76-8) + 5-bromo-1,3-xylene (556-96-7) → (2-aminophenyl)(3,5-dimethylphenyl)methanone (83465-82-1)

Guidance literature:

inverse addition of the Grignard reagent;

DOI:10.1039/P29860000405

Reference yield:

5-bromo-1,3-xylene (556-96-7) + anthranilic acid N-methoxy-N-methylamide (133776-41-7) → (2-aminophenyl)(3,5-dimethylphenyl)methanone (83465-82-1)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; at -78 ℃; Inert atmosphere;

DOI:10.1021/acs.joc.9b01418

upstream raw materials:

2-methyl-4-oxo-3,1-benzoxazine

5-bromo-1,3-xylene

anthranilic acid nitrile

3,5-dimethyphenylmagnesium bromide

Downstream raw materials:

4-(3,5-dimethylphenyl)-2,1,3-benzothiadiazine 2,2-dioxide

4-(3',5'-dimethylphenyl)-2-methylquinoline

3,5-dimethylphenyl 2-iodophenyl ketone

2,4-dimethyl-9-phenylfluoren-9-ol

Refernces

• 1、 Li, Quanzhe,Liu, Jiaxin,Shi, Min,Wei, Yin. "Visible Light Induced Cyclization to Spirobi[indene] Skeletons from Functionalized Alkylidienecyclopropanes". supporting information. . Retrieved 2020/03/26.
• 2、 Fan, Xing,Shi, Min,Wei, Yin. "Palladium-Catalyzed Cascade Reductive and Carbonylative Cyclization of Ortho-Iodo-Tethered Methylenecyclopropanes (MCPs) Using N-Formylsaccharin as CO Source". supporting information. p. 5677 - 5683. Retrieved 2019/11/16.