CID 657389

Base Information

• Chemical Name: CID 657389
• CAS No.: 2016-88-8
• Molecular Formula: C6H8ClN7O^.HCl
• Molecular Weight: 266.09
• Hs Code.: 29339980
• Mol file: 2016-88-8.mol

Synonyms:AKOS015917993

Chemical Property of CID 657389

Chemical Property:

• Appearance/Colour: Pale yellow solid
• Vapor Pressure: 1.08E-15mmHg at 25°C
• Melting Point: 293-294 °C
• Boiling Point: 628.1 °C at 760 mmHg
• Flash Point: 333.7 °C
• PSA: 156.79000
• Density: 2.11 g/cm3
• LogP: 2.07300
• Storage Temp.: Store at RT
• Solubility.: H2O: 50 mg/mL, clear, yellow-green
• Water Solubility.: <0.1 g/100 mL at 19.5℃
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 1
• Exact Mass: 265.0245633
• Heavy Atom Count: 16
• Complexity: 279

Purity/Quality:

98.0%-101.0% ^*data from raw suppliers

Amiloride hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T,Xi
• Hazard Codes: T,Xi
• Statements: 25-36/37/38
• Safety Statements: 36-45-26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: [H+].C1(=C(N=C(C(=N1)Cl)N)N)C(=O)N=C(N)N.[Cl-]
• Uses: Sodium channel blocker. Diuretic. Na+ channel inhibitor, diuretic A calcium channel andsodium channel protein inhibitor
• Therapeutic Function: Diuretic
• Clinical Use: Oedema Potassium conservation with thiazide and loop diuretics
• Drug interactions: Potentially hazardous interactions with other drugs ACE inhibitor and angiotensin-II antagonists: increased risk of hyperkalaemia and hypotension. Antibacterials: avoid concomitant use with lymecycline. Antidepressants: increased risk of postural hypotension with tricyclics; enhanced hypotensive effect with MAOIs. Antihypertensives: enhanced hypotensive effect. Ciclosporin: increased risk of hyperkalaemia and nephrotoxicity. Cytotoxics: increased risk of nephrotoxicity and ototoxicity with platinum compounds. Lithium excretion reduced NSAIDS: increased risk of hyperkalaemia; increased risk of nephrotoxicity; antagonism of diuretic effect. Potassium salts: increased risk of hyperkalaemia. Tacrolimus: increased risk of hyperkalaemia.

Technology Process of CID 657389

There total 1 articles about CID 657389 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ amiloride hydrochloride (2016-88-8)

Guidance literature:

Refernces

• 1、 -. "2,3-Dihydro-2,6,7-trisubstituted-5-acylbenzofurans". . . Retrieved 2008/06/13.