4-METHOXY-3-CHLOROPYRIDINE

Base Information

• Chemical Name: 4-METHOXY-3-CHLOROPYRIDINE
• CAS No.: 89379-79-3
• Molecular Formula: C₆H₆ClNO
• Molecular Weight: 143.573
• Hs Code.: 2933399090
• Mol file: 89379-79-3.mol

Synonyms:4-METHOXY-3-CHLOROPYRIDINE

Chemical Property of 4-METHOXY-3-CHLOROPYRIDINE

Chemical Property:

• Vapor Pressure: 0.591mmHg at 25°C
• Boiling Point: 195.335°C at 760 mmHg
• Flash Point: 71.936°C
• PSA: 22.12000
• Density: 1.21g/cm³
• LogP: 1.74360
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99.00% ^*data from raw suppliers

3-Chloro-4-methoxypyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Chloro-4-methoxypyridine is used in preparation of Furo- and Thieno-Pyridine Carboxamides useful as Pim kinase inhibitors for treating proliferative and immune disorders.

Technology Process of 4-METHOXY-3-CHLOROPYRIDINE

There total 4 articles about 4-METHOXY-3-CHLOROPYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

3-chloro-4-nitropyridine (13194-60-0) + sodium methylate (124-41-4) → 3-Chlor-4-methoxy-pyridin (89379-79-3)

Guidance literature:

In methanol; at 20 ℃; for 2h;

Reference yield: 56.0%

methanol (67-56-1) + 3-chloro-4-hydroxypyridine (89284-20-8) → 3-Chlor-4-methoxy-pyridin (89379-79-3)

Guidance literature:

With diazomethyl-trimethyl-silane; In hexane; toluene; at 0 - 30 ℃; for 64.5h;

Reference yield:

→ 3-Chlor-4-methoxy-pyridin (89379-79-3)

Guidance literature:

With copper; copper(l) chloride;

upstream raw materials:

methanol

3-chloro-4-hydroxypyridine

3-chloro-4-nitropyridine

sodium methylate

Refernces

• 1、 -. "FURO- AND THIENO-PYRIDINE CARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS". Paragraph 0859; 0860; 0861. . Retrieved 2015/03/04.